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10.1016/j.ijid.2020.05.106 http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.05.106 32492530!7261468!32492530     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2020 ; 97 (ä): 313-321 Nephropedia Template TP {{tp|p=32492530|t=2020. Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity |pdf=|usr=}}{{32492530}} gab.com Text Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32492530 #FOAvip OBJECTIVES: We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases. METHODS: We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation </=93% at room air. Expressions of molecules related to T-cell activation and functions were analyzed by flow cytometry. RESULTS: The population dynamics of T cells at the first week were not different between the two groups. However, total numbers of CD4(+) and CD8(+) T cells tended to be lower in the severe group at the third week of illness. Expressions of Ki-67, PD-1, perforin, and granzyme B in CD4(+) or CD8(+) T cells were significantly higher in the severe group than in the mild group at the third week. In contrast to the mild group, the levels of their expression did not decrease in the severe group. CONCLUSIONS: Severe COVID-19 had a higher degree of proliferation, activation, and cytotoxicity of T-cells at the late phase of illness without cytotoxic T-cell contraction, which might contribute to the development of severe COVID-19. Twit Text FOAVip Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32492530 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32492530 #FOAvip English Wikipedia <ref>{{Cite pmid|32492530}}</ref> Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity #MMPMID32492530 Kang CK; Han GC; Kim M; Kim G; Shin HM; Song KH; Choe PG; Park WB; Kim ES; Kim HB; Kim NJ; Kim HR; Oh MD Int J Infect Dis 2020[Aug]; 97 (ä): 313-321 PMID32492530show ga OBJECTIVES: We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases. METHODS: We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation |*Immunity, Cellular[MESH] |*Lymphocyte Activation[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/physiopathology[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Granzymes[MESH] |Humans[MESH] |Ki-67 Antigen[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Perforin[MESH] |Pneumonia, Viral/*immunology/physiopathology[MESH] |Programmed Cell Death 1 Receptor[MESH] |SARS-CoV-2[MESH]Aberrant hyperactivation of cytotoxic T-cell as a potential determinan(epmc).pdf DeepDyve Pubget Overpricing