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10.1016/j.virusres.2020.198036

http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198036
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32492472!7483349!32492472
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suck abstract from ncbi

pmid32492472      Virus+Res 2020 ; 286 (ä): 198036
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  • How ISG15 combats viral infection #MMPMID32492472
  • Freitas BT; Scholte FEM; Bergeron E; Pegan SD
  • Virus Res 2020[Sep]; 286 (ä): 198036 PMID32492472show ga
  • Interferon (IFN)-stimulated gene product 15 (ISG15) is a ubiquitin-like protein critical for the control of microbial infections. ISG15 appears to serve a wide variety of functions, which regulate multiple cellular responses contributing to the development of an antiviral state. ISG15 is a versatile molecule directly modulating both host and virus protein function which regulate many signaling pathways, including its own synthesis. Here we review the various roles ISG15 plays in the antiviral immune response, and examine the mechanisms by which viruses attempt to mitigate or exploit ISG15 activity.
  • |Animals[MESH]
  • |Cytokines/genetics/*metabolism[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/*immunology[MESH]
  • |Interferon Type I/immunology[MESH]
  • |Macrophages/immunology[MESH]
  • |Mice[MESH]
  • |Neutrophils/immunology[MESH]
  • |Signal Transduction/genetics/immunology[MESH]
  • |Ubiquitins/genetics/*metabolism[MESH]
  • |Viral Proteins/metabolism[MESH]
  • |Virus Diseases/*immunology[MESH]
  • |Virus Internalization[MESH]


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