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10.1016/j.celrep.2020.107720 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.107720 32492428!7265846!32492428     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 31 (9): 107720 Nephropedia Template TP {{tp|p=32492428|t=2020. Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity |pdf=|usr=}}{{32492428}} gab.com Text Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32492428 #FOAvip Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molecular program in mature NK cell biology is unclear. To address this, we develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice. Eomes deletion after normal NK cell ontogeny results in a rapid loss of NK cells (but not ILC1s), with a particularly profound effect on penultimately mature stage III NK cells. Mechanisms responsible for stage III reduction include increased apoptosis and impaired maturation from stage II precursors. Induced Eomes deletion also decreases NK cell cytotoxicity and abrogates in vivo rejection of major histocompatibility complex (MHC)-class-I-deficient cells. However, other NK cell functional responses, and stage IV NK cells, are largely preserved. These data indicate that mature NK cells have distinct Eomes-dependent and -independent stages. Twit Text FOAVip Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32492428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32492428 #FOAvip English Wikipedia <ref>{{Cite pmid|32492428}}</ref> Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity #MMPMID32492428 Wagner JA; Wong P; Schappe T; Berrien-Elliott MM; Cubitt C; Jaeger N; Lee M; Keppel CR; Marin ND; Foltz JA; Marsala L; Neal CC; Sullivan RP; Schneider SE; Keppel MP; Saucier N; Cooper MA; Fehniger TA Cell Rep 2020[Jun]; 31 (9): 107720 PMID32492428show ga Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molecular program in mature NK cell biology is unclear. To address this, we develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice. Eomes deletion after normal NK cell ontogeny results in a rapid loss of NK cells (but not ILC1s), with a particularly profound effect on penultimately mature stage III NK cells. Mechanisms responsible for stage III reduction include increased apoptosis and impaired maturation from stage II precursors. Induced Eomes deletion also decreases NK cell cytotoxicity and abrogates in vivo rejection of major histocompatibility complex (MHC)-class-I-deficient cells. However, other NK cell functional responses, and stage IV NK cells, are largely preserved. These data indicate that mature NK cells have distinct Eomes-dependent and -independent stages. |Animals[MESH] |Antigens, Ly/genetics/metabolism[MESH] |Apoptosis[MESH] |Cell Cycle Checkpoints[MESH] |Histocompatibility Antigens Class I/genetics/metabolism[MESH] |Killer Cells, Natural/cytology/*immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |Natural Cytotoxicity Triggering Receptor 1/genetics/metabolism[MESH] |Receptors, Interleukin-15/metabolism[MESH] |STAT5 Transcription Factor/metabolism[MESH] |Signal Transduction[MESH] |Spleen/cytology/immunology[MESH]Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and(epmc).pdf DeepDyve Pubget Overpricing