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10.1002/ppul.24885

http://scihub22266oqcxt.onion/10.1002/ppul.24885
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32492251!7300659!32492251
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suck abstract from ncbi


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pmid32492251      Pediatr+Pulmonol 2020 ; 55 (8): 1892-1899
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  • Clinical manifestations of children with COVID-19: A systematic review #MMPMID32492251
  • de Souza TH; Nadal JA; Nogueira RJN; Pereira RM; Brandao MB
  • Pediatr Pulmonol 2020[Aug]; 55 (8): 1892-1899 PMID32492251show ga
  • BACKGROUND: The coronavirus disease 2019 (COVID-19) outbreak is an unprecedented global public health challenge, leading to thousands of deaths every day worldwide. Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19. METHODS: The Medline database was searched between December 1st 2019 and April 6th 2020. No language restrictions were applied. Inclusion criteria were (a) studied patients younger than 18 years old; (b) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (c) contained descriptions of clinical manifestations, laboratory tests, or radiological examinations. RESULTS: A total of 38 studies (1124 cases) were included. From all the cases, 1117 had their severity classified: 14.2% were asymptomatic, 36.3% were mild, 46.0% were moderate, 2.1% were severe, and 1.2% were critical. The most prevalent symptom was fever (47.5%), followed by cough (41.5%), nasal symptoms (11.2%), diarrhea (8.1%), and nausea/vomiting (7.1%). One hundred forty-five (36.9%) children were diagnosed with pneumonia and 43 (10.9%) upper airway infections were reported. Reduced lymphocyte count was reported in 12.9% of cases. Abnormalities in computed tomography were reported in 63.0% of cases. The most prevalent abnormalities reported were ground-glass opacities, patchy shadows, and consolidations. Only one death was reported. CONCLUSIONS: Clinical manifestations of children with COVID-19 differ widely from adult cases. Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children.
  • |Adolescent[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/*diagnosis/diagnostic imaging/epidemiology[MESH]
  • |Cough/*etiology[MESH]
  • |Erythema/etiology[MESH]
  • |Female[MESH]
  • |Fever/*etiology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/diagnostic imaging/epidemiology[MESH]
  • |Prognosis[MESH]
  • |Respiratory Tract Infections/etiology[MESH]
  • |SARS-CoV-2[MESH]
  • |Tachycardia/etiology[MESH]
  • |Tachypnea/etiology[MESH]
  • |Tomography, X-Ray Computed[MESH]


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