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10.1002/jmv.26104 http://scihub22266oqcxt.onion/10.1002/jmv.26104 32492183!7300971!32492183     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (10): 2232-2237 Nephropedia Template TP {{tp|p=32492183|t=2020. Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission |pdf=|usr=}}{{32492183}} gab.com Text Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32492183 #FOAvip Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation. Twit Text FOAVip Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32492183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32492183 #FOAvip English Wikipedia <ref>{{Cite pmid|32492183}}</ref> Evidence for mutations in SARS-CoV-2 Italian isolates potentially affecting virus transmission #MMPMID32492183 Benvenuto D; Demir AB; Giovanetti M; Bianchi M; Angeletti S; Pascarella S; Cauda R; Ciccozzi M; Cassone A J Med Virol 2020[Oct]; 92 (10): 2232-2237 PMID32492183show ga Italy is the first western country suffering heavy severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and disease impact after coronavirus disease-2019 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has not been evaluated. We have compared SARS-CoV-2 genome sequences from Italian patients with virus sequences from Chinese patients. We focussed upon three nonsynonymous mutations of genes coding for S(one) and N (two) viral proteins present in Italian isolates and absent in Chinese ones, using various bioinformatics tools. Amino acid analysis and changes in three-dimensional protein structure suggests the mutations reduce protein stability and, particularly for S1 mutation, the enhanced torsional ability of the molecule could favor virus binding to cell receptor(s). This theoretical interpretation awaits experimental and clinical confirmation. |*Genome, Viral[MESH] |*Pandemics[MESH] |Amino Acid Substitution[MESH] |COVID-19/*epidemiology/pathology/*transmission/virology[MESH] |China/epidemiology[MESH] |Coronavirus Nucleocapsid Proteins/*chemistry/genetics[MESH] |Evolution, Molecular[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Models, Molecular[MESH] |Molecular Epidemiology[MESH] |Mutation[MESH] |Phosphoproteins/chemistry/genetics[MESH] |Phylogeny[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |SARS-CoV-2/classification/*genetics[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/genetics[MESH] |Travel[MESH]Evidence for mutations in SARS-CoV-2 Italian isolates potentially affe(epmc).pdf DeepDyve Pubget Overpricing