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10.1152/ajplung.00183.2020 http://scihub22266oqcxt.onion/10.1152/ajplung.00183.2020 32491949!7324935!32491949     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Lung+Cell+Mol+Physiol 2020 ; 319 (1): L39-L44 Nephropedia Template TP {{tp|p=32491949|t=2020. Understanding the age divide in COVID-19: why are children overwhelmingly spared?|pdf=|usr=}}{{32491949}} gab.com Text Understanding the age divide in COVID-19: why are children overwhelmingly spared JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32491949 #FOAvip The rapid emergence and subsequent global dissemination of SARS-CoV-2 disease (COVID-19) has resulted in over 4 million cases worldwide. The disease has a marked predilection for adults, and children are relatively spared. Understanding the age-based differences in pathophysiological pathways and processes relevant to the onset and progression of disease both in the clinical course and in experimental disease models may hold the key to the identification of therapeutic targets. The differences in the clinical course are highlighted by the lack of progression of the SARS-CoV-2 infection beyond mild symptoms in a majority of children, whereas in adults the disease progresses to acute lung injury and an acute respiratory distress syndrome (ARDS)-like phenotype with high mortality. The pathophysiological mechanisms leading to decreased lung injury in children may involve the decreased expression of the mediators necessary for viral entry into the respiratory epithelium and differences in the immune system responses in children. Specifically, decreased expression of proteins, including angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in the airway epithelium in children may prevent viral entry. The immune system differences may include a relative preponderance of CD4(+) T cells, decreased neutrophil infiltration, decreased production of proinflammatory cytokines, and increased production of immunomodulatory cytokines in children compared with adults. Notably, the developing lung in children may have a greater capacity to recover and repair after viral infection. Understanding the relative contributions of the above processes to the protective phenotype in the developing lung can guide the trial of the appropriate therapies in adults. Twit Text FOAVip Understanding the age divide in COVID-19: why are children overwhelmingly spared ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32491949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32491949 #FOAvip English Wikipedia <ref>{{Cite pmid|32491949}}</ref> Understanding the age divide in COVID-19: why are children overwhelmingly spared? #MMPMID32491949 Lingappan K; Karmouty-Quintana H; Davies J; Akkanti B; Harting MT Am J Physiol Lung Cell Mol Physiol 2020[Jul]; 319 (1): L39-L44 PMID32491949show ga The rapid emergence and subsequent global dissemination of SARS-CoV-2 disease (COVID-19) has resulted in over 4 million cases worldwide. The disease has a marked predilection for adults, and children are relatively spared. Understanding the age-based differences in pathophysiological pathways and processes relevant to the onset and progression of disease both in the clinical course and in experimental disease models may hold the key to the identification of therapeutic targets. The differences in the clinical course are highlighted by the lack of progression of the SARS-CoV-2 infection beyond mild symptoms in a majority of children, whereas in adults the disease progresses to acute lung injury and an acute respiratory distress syndrome (ARDS)-like phenotype with high mortality. The pathophysiological mechanisms leading to decreased lung injury in children may involve the decreased expression of the mediators necessary for viral entry into the respiratory epithelium and differences in the immune system responses in children. Specifically, decreased expression of proteins, including angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in the airway epithelium in children may prevent viral entry. The immune system differences may include a relative preponderance of CD4(+) T cells, decreased neutrophil infiltration, decreased production of proinflammatory cytokines, and increased production of immunomodulatory cytokines in children compared with adults. Notably, the developing lung in children may have a greater capacity to recover and repair after viral infection. Understanding the relative contributions of the above processes to the protective phenotype in the developing lung can guide the trial of the appropriate therapies in adults. |*Betacoronavirus[MESH] |Adult[MESH] |Age Distribution[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Child[MESH] |Coronavirus Infections/diagnosis/*drug therapy/virology[MESH] |Cytokines/blood[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/immunology/*metabolism[MESH] |Pneumonia, Viral/diagnosis/*drug therapy/virology[MESH] |SARS-CoV-2[MESH]Understanding the age divide in COVID-19: why are children overwhelmin(epmc).pdf DeepDyve Pubget Overpricing