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10.6061/clinics/2020/e1980 http://scihub22266oqcxt.onion/10.6061/clinics/2020/e1980 32490931!7233687!32490931     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clinics+(Sao+Paulo) 2020 ; 75 (ä): e1980 Nephropedia Template TP {{tp|p=32490931|t=2020. 17beta-Estradiol, a potential ally to alleviate SARS-CoV-2 infection |pdf=|usr=}}{{32490931}} gab.com Text 17beta-Estradiol, a potential ally to alleviate SARS-CoV-2 infection JO: Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=32490931 #FOAvip Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed that the viral infection induces a vascular process in the lung, which included vasodilation and endothelial dysfunction. Further, the proportions of CD4+ T and CD8+ T lymphocytes were strongly reduced in patients with severe SARS-CoV-2 infection. Estradiol is connected with CD4+ T cell numbers and increases T-reg cell populations, affecting immune responses to infection. It is known that estradiol exerts a protective effect on endothelial function, activating the generation of nitric oxide (NO) via endothelial nitric oxide synthase. Estrogen attenuates the vasoconstrictor response to various stimuli and induces vasodilation in the pulmonary vasculature during stress situations like hypoxia. It exerts a variety of rapid actions, which are initiated after its coupling with membrane receptors, which in turn, may positively modulate vascular responses in pulmonary disease and help to maintain microvascular flow. Direct and indirect mechanisms underlying the effects of estradiol were investigated, and the results point to a possible protective effect of estradiol against COVID-19, indicating that it may be considered as an adjuvant therapeutic element for the treatment of patients affected by the novel coronavirus. Twit Text FOAVip 17beta-Estradiol, a potential ally to alleviate SARS-CoV-2 infection ????Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=32490931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32490931 #FOAvip English Wikipedia <ref>{{Cite pmid|32490931}}</ref> 17beta-Estradiol, a potential ally to alleviate SARS-CoV-2 infection #MMPMID32490931 Breithaupt-Faloppa AC; Correia CJ; Prado CM; Stilhano RS; Ureshino RP; Moreira LFP Clinics (Sao Paulo) 2020[]; 75 (ä): e1980 PMID32490931show ga Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed that the viral infection induces a vascular process in the lung, which included vasodilation and endothelial dysfunction. Further, the proportions of CD4+ T and CD8+ T lymphocytes were strongly reduced in patients with severe SARS-CoV-2 infection. Estradiol is connected with CD4+ T cell numbers and increases T-reg cell populations, affecting immune responses to infection. It is known that estradiol exerts a protective effect on endothelial function, activating the generation of nitric oxide (NO) via endothelial nitric oxide synthase. Estrogen attenuates the vasoconstrictor response to various stimuli and induces vasodilation in the pulmonary vasculature during stress situations like hypoxia. It exerts a variety of rapid actions, which are initiated after its coupling with membrane receptors, which in turn, may positively modulate vascular responses in pulmonary disease and help to maintain microvascular flow. Direct and indirect mechanisms underlying the effects of estradiol were investigated, and the results point to a possible protective effect of estradiol against COVID-19, indicating that it may be considered as an adjuvant therapeutic element for the treatment of patients affected by the novel coronavirus. |*Betacoronavirus[MESH] |*Immunity, Innate[MESH] |Animals[MESH] |COVID-19[MESH] |Coronavirus Infections/*therapy[MESH] |Estradiol/*therapeutic use[MESH] |Female[MESH] |Humans[MESH] |Inflammation/drug therapy/*virology[MESH] |Male[MESH] |Pandemics[MESH] |Pneumonia, Viral/*therapy[MESH] |Rats[MESH] |SARS-CoV-2[MESH]17beta-Estradiol, a potential ally to alleviate SARS-CoV-2 infection (epmc).pdf DeepDyve Pubget Overpricing