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10.1093/pubmed/fdaa074

http://scihub22266oqcxt.onion/10.1093/pubmed/fdaa074
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suck abstract from ncbi


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pmid32490532      J+Public+Health+(Oxf) 2020 ; 42 (3): 493-503
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  • HyPE study: hydroxychloroquine prophylaxis-related adverse events analysis among healthcare workers during COVID-19 pandemic: a rising public health concern #MMPMID32490532
  • Nagaraja BS; Ramesh KN; Dhar D; Mondal MS; Dey T; Saha S; Khan MA; Rutul SD; Pratik K; Manjula J; Sangeeth TA; Singh V
  • J Public Health (Oxf) 2020[Aug]; 42 (3): 493-503 PMID32490532show ga
  • BACKGROUND: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. METHODS: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. RESULTS: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG. CONCLUSIONS: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
  • |Adult[MESH]
  • |Antiviral Agents/*adverse effects/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*adverse effects/*therapeutic use[MESH]
  • |Incidence[MESH]
  • |India/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology[MESH]
  • |Public Health/*statistics & numerical data[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]


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