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10.1016/j.antiviral.2020.104823 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104823 32485209!7261112!32485209     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2020 ; 180 (ä): 104823 Nephropedia Template TP {{tp|p=32485209|t=2020. Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway |pdf=|usr=}}{{32485209}} gab.com Text Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32485209 #FOAvip Although rotavirus infection is usually acute and self-limiting, it can cause chronic infection with severe diseases in immunocompromised patients, including organ transplantation recipients and cancer patients irrespective of pediatric or adult patients. Since no approved medication against rotavirus infection is available, this study screened a library of safe-in-man broad-spectrum antivirals. We identified gemcitabine, a widely used anti-cancer drug, as a potent inhibitor of rotavirus infection. We confirmed this effect in 2D cell cultures and 3D cultured human intestinal organoids with both laboratory-adapted rotavirus strains and five clinical isolates. Supplementation of UTP or uridine largely abolished the anti-rotavirus activity of gemcitabine, suggesting its function through inhibition of pyrimidine biosynthesis pathway. Our results support repositioning of gemcitabine for treating rotavirus infection, especially for infected cancer patients. Twit Text FOAVip Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32485209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32485209 #FOAvip English Wikipedia <ref>{{Cite pmid|32485209}}</ref> Drug screening identifies gemcitabine inhibiting rotavirus through alteration of pyrimidine nucleotide synthesis pathway #MMPMID32485209 Chen S; Wang Y; Li P; Yin Y; Bijvelds MJ; de Jonge HR; Peppelenbosch MP; Kainov DE; Pan Q Antiviral Res 2020[Aug]; 180 (ä): 104823 PMID32485209show ga Although rotavirus infection is usually acute and self-limiting, it can cause chronic infection with severe diseases in immunocompromised patients, including organ transplantation recipients and cancer patients irrespective of pediatric or adult patients. Since no approved medication against rotavirus infection is available, this study screened a library of safe-in-man broad-spectrum antivirals. We identified gemcitabine, a widely used anti-cancer drug, as a potent inhibitor of rotavirus infection. We confirmed this effect in 2D cell cultures and 3D cultured human intestinal organoids with both laboratory-adapted rotavirus strains and five clinical isolates. Supplementation of UTP or uridine largely abolished the anti-rotavirus activity of gemcitabine, suggesting its function through inhibition of pyrimidine biosynthesis pathway. Our results support repositioning of gemcitabine for treating rotavirus infection, especially for infected cancer patients. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Biosynthetic Pathways[MESH] |Caco-2 Cells[MESH] |Deoxycytidine/*analogs & derivatives/pharmacology[MESH] |Drug Evaluation, Preclinical[MESH] |Gemcitabine[MESH] |High-Throughput Screening Assays[MESH] |Humans[MESH] |Intestines/drug effects/virology[MESH] |Macaca mulatta/virology[MESH] |Organoids/drug effects/virology[MESH] |Pyrimidines/*biosynthesis[MESH] |Rotavirus Infections/virology[MESH] |Rotavirus/*drug effects[MESH]Drug screening identifies gemcitabine inhibiting rotavirus through alt(epmc).pdf DeepDyve Pubget Overpricing