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10.1002/anie.202006164 http://scihub22266oqcxt.onion/10.1002/anie.202006164 32485007!7383588!32485007     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2020 ; 59 (30): 12534-12540 Nephropedia Template TP {{tp|p=32485007|t=2020. C7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis |pdf=|usr=}}{{32485007}} gab.com Text C7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=32485007 #FOAvip C7-H-functionalized indoles are ubiquitous structural units of biological and pharmaceutical compounds for numerous antiviral agents against SARS-CoV or HIV-1. Thus, achieving site-selective functionalizations of the C7-H position of indoles, while discriminating among other bonds, is in high demand. Herein, we disclose site-selective C7-H activations of indoles by ruthenium(II) biscarboxylate catalysis under mild conditions. Base-assisted internal electrophilic-type substitution C-H ruthenation by weak O-coordination enabled the C7-H functionalization of indoles and offered a broad scope, including C-N and C-C bond formation. The versatile ruthenium-catalyzed C7-H activations were characterized by gram-scale syntheses and the traceless removal of the directing group, thus providing easy access to pharmaceutically relevant scaffolds. Detailed mechanistic studies through spectroscopic and spectrometric analyses shed light on the unique nature of the robust ruthenium catalysis for the functionalization of the C7-H position of indoles. Twit Text FOAVip C7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=32485007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32485007 #FOAvip English Wikipedia <ref>{{Cite pmid|32485007}}</ref> C7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis #MMPMID32485007 Choi I; Messinis AM; Ackermann L Angew Chem Int Ed Engl 2020[Jul]; 59 (30): 12534-12540 PMID32485007show ga C7-H-functionalized indoles are ubiquitous structural units of biological and pharmaceutical compounds for numerous antiviral agents against SARS-CoV or HIV-1. Thus, achieving site-selective functionalizations of the C7-H position of indoles, while discriminating among other bonds, is in high demand. Herein, we disclose site-selective C7-H activations of indoles by ruthenium(II) biscarboxylate catalysis under mild conditions. Base-assisted internal electrophilic-type substitution C-H ruthenation by weak O-coordination enabled the C7-H functionalization of indoles and offered a broad scope, including C-N and C-C bond formation. The versatile ruthenium-catalyzed C7-H activations were characterized by gram-scale syntheses and the traceless removal of the directing group, thus providing easy access to pharmaceutically relevant scaffolds. Detailed mechanistic studies through spectroscopic and spectrometric analyses shed light on the unique nature of the robust ruthenium catalysis for the functionalization of the C7-H position of indoles. äC7-Indole Amidations and Alkenylations by Ruthenium(II) Catalysis (epmc).pdf DeepDyve Pubget Overpricing