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10.1002/jmv.26103

http://scihub22266oqcxt.onion/10.1002/jmv.26103
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32484958!7301002!32484958
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suck abstract from ncbi


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pmid32484958      J+Med+Virol 2020 ; 92 (10): 2227-2231
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  • Clearance and persistence of SARS-CoV-2 RNA in patients with COVID-19 #MMPMID32484958
  • Carmo A; Pereira-Vaz J; Mota V; Mendes A; Morais C; da Silva AC; Camilo E; Pinto CS; Cunha E; Pereira J; Coucelo M; Martinho P; Correia L; Marques G; Araujo L; Rodrigues F
  • J Med Virol 2020[Oct]; 92 (10): 2227-2231 PMID32484958show ga
  • Patients with coronavirus disease-2019 may be discharged based on clinical resolution of symptoms, and evidence for viral RNA clearance from the upper respiratory tract. Understanding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral clearance profile is crucial to establish a re-testing plan on discharge and ending isolation of patients. We aimed to evaluate the number of days that a patient needed to achieve undetectable levels of SARS-CoV-2 in upper respiratory tract specimens (nasopharyngeal swab and/or an oropharyngeal swab). The clearance and persistence of viral RNA was evaluated in two groups of positive patients: those who achieved two negative reverse transcription-polymerase chain reaction (RT-PCR) tests and those who kept testing positive. Patients were organized thereafter in two subgroups, mild illness patients discharged home and inpatients who had moderate to severe illness. Results from RT-PCR tests were then correlated with results from the evaluation of the immune response. The study evidenced that most patients tested positive for more than 2 weeks and that persistence of viral RNA is not necessarily associated with severe disease but may result from a weaker immune response instead.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Testing/methods[MESH]
  • |COVID-19/*diagnosis/immunology/pathology/virology[MESH]
  • |Child[MESH]
  • |Convalescence[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Oropharynx/virology[MESH]
  • |Patient Discharge/*statistics & numerical data[MESH]
  • |RNA, Viral/*genetics[MESH]
  • |Retrospective Studies[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/*genetics/immunology/pathogenicity[MESH]


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