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10.1093/bib/bbaa114 http://scihub22266oqcxt.onion/10.1093/bib/bbaa114 32484220!7314185!32484220     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (2): 1150-1160 Nephropedia Template TP {{tp|p=32484220|t=2021. Discovery of G-quadruplex-forming sequences in SARS-CoV-2 |pdf=|usr=}}{{32484220}} gab.com Text Discovery of G-quadruplex-forming sequences in SARS-CoV-2 JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32484220 #FOAvip The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms. We have analyzed and identified 25 four contiguous GG runs (G2NxG2NyG2NzG2) in the SARS-CoV-2 RNA genome, suggesting putative G-quadruplex-forming sequences (PQSs). Detailed analysis of SARS-CoV-2 PQSs revealed their locations in the open reading frames of ORF1 ab, spike (S), ORF3a, membrane (M) and nucleocapsid (N) genes. Identical PQSs were also found in the other members of the Coronaviridae family. The top-ranked PQSs at positions 13385 and 24268 were confirmed to form RNA G-quadruplex structures in vitro by multiple spectroscopic assays. Furthermore, their direct interactions with viral helicase (nsp13) were determined by microscale thermophoresis. Molecular docking model suggests that nsp13 distorts the G-quadruplex structure by allowing the guanine bases to be flipped away from the guanine quartet planes. Targeting viral helicase and G-quadruplex structure represents an attractive approach for potentially inhibiting the SARS-CoV-2 virus. Twit Text FOAVip Discovery of G-quadruplex-forming sequences in SARS-CoV-2 ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32484220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32484220 #FOAvip English Wikipedia <ref>{{Cite pmid|32484220}}</ref> Discovery of G-quadruplex-forming sequences in SARS-CoV-2 #MMPMID32484220 Ji D; Juhas M; Tsang CM; Kwok CK; Li Y; Zhang Y Brief Bioinform 2021[Mar]; 22 (2): 1150-1160 PMID32484220show ga The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms. We have analyzed and identified 25 four contiguous GG runs (G2NxG2NyG2NzG2) in the SARS-CoV-2 RNA genome, suggesting putative G-quadruplex-forming sequences (PQSs). Detailed analysis of SARS-CoV-2 PQSs revealed their locations in the open reading frames of ORF1 ab, spike (S), ORF3a, membrane (M) and nucleocapsid (N) genes. Identical PQSs were also found in the other members of the Coronaviridae family. The top-ranked PQSs at positions 13385 and 24268 were confirmed to form RNA G-quadruplex structures in vitro by multiple spectroscopic assays. Furthermore, their direct interactions with viral helicase (nsp13) were determined by microscale thermophoresis. Molecular docking model suggests that nsp13 distorts the G-quadruplex structure by allowing the guanine bases to be flipped away from the guanine quartet planes. Targeting viral helicase and G-quadruplex structure represents an attractive approach for potentially inhibiting the SARS-CoV-2 virus. |*G-Quadruplexes[MESH] |COVID-19/*virology[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Open Reading Frames[MESH]Discovery of G-quadruplex-forming sequences in SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing