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10.4269/ajtmh.20-0516

http://scihub22266oqcxt.onion/10.4269/ajtmh.20-0516
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32484155!7410484!32484155
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suck abstract from ncbi


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pmid32484155      Am+J+Trop+Med+Hyg 2020 ; 103 (2): 572-577
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  • Malaria and Parasitic Neglected Tropical Diseases: Potential Syndemics with COVID-19? #MMPMID32484155
  • Gutman JR; Lucchi NW; Cantey PT; Steinhardt LC; Samuels AM; Kamb ML; Kapella BK; McElroy PD; Udhayakumar V; Lindblade KA
  • Am J Trop Med Hyg 2020[Aug]; 103 (2): 572-577 PMID32484155show ga
  • The COVID-19 pandemic, caused by SARS-CoV-2, have surpassed 5 million cases globally. Current models suggest that low- and middle-income countries (LMICs) will have a similar incidence but substantially lower mortality rate than high-income countries. However, malaria and neglected tropical diseases (NTDs) are prevalent in LMICs, and coinfections are likely. Both malaria and parasitic NTDs can alter immunologic responses to other infectious agents. Malaria can induce a cytokine storm and pro-coagulant state similar to that seen in severe COVID-19. Consequently, coinfections with malaria parasites and SARS-CoV-2 could result in substantially worse outcomes than mono-infections with either pathogen, and could shift the age pattern of severe COVID-19 to younger age-groups. Enhancing surveillance platforms could provide signals that indicate whether malaria, NTDs, and COVID-19 are syndemics (synergistic epidemics). Based on the prevalence of malaria and NTDs in specific localities, efforts to characterize COVID-19 in LMICs could be expanded by adding testing for malaria and NTDs. Such additional testing would allow the determination of the rates of coinfection and comparison of severity of outcomes by infection status, greatly improving the understanding of the epidemiology of COVID-19 in LMICs and potentially helping to mitigate its impact.
  • |*Syndemic[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coinfection/epidemiology/parasitology/virology[MESH]
  • |Coronavirus Infections/*epidemiology[MESH]
  • |Developing Countries[MESH]
  • |Humans[MESH]
  • |Malaria/*epidemiology[MESH]
  • |Neglected Diseases/epidemiology[MESH]
  • |Pandemics[MESH]
  • |Parasitic Diseases/*epidemiology[MESH]
  • |Pneumonia, Viral/*epidemiology[MESH]
  • |SARS-CoV-2[MESH]


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