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10.7150/thno.46691

http://scihub22266oqcxt.onion/10.7150/thno.46691
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32483428!7254986!32483428
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suck abstract from ncbi


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pmid32483428      Theranostics 2020 ; 10 (13): 5932-5942
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  • Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients #MMPMID32483428
  • Itani R; Tobaiqy M; Al Faraj A
  • Theranostics 2020[]; 10 (13): 5932-5942 PMID32483428show ga
  • On the 30(th) of January 2020, the World Health Organization fired up the sirens against a fast spreading infectious disease caused by a newly discovered Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and gave this disease the name COVID-19. While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe. In the last decade, theranostic nanoparticles were reported as promising tool for efficiently and selectively deliver therapeutic moieties (i.e. drugs, vaccines, siRNA, peptide) to target sites of infection. In addition, they allow monitoring infectious sides and treatment responses using noninvasive imaging modalities. While intranasal delivery was proposed as the preferred administration route for therapeutic agents against viral pulmonary diseases, NP-based delivery systems offer numerous benefits to overcome challenges associated with mucosal administration, and ensure that these agents achieve a concentration that is many times higher than expected in the targeted sites of infection while limiting side effects on normal cells. In this article, we have shed light on the promising role of nanoparticles as effective carriers for therapeutics or immune modulators to help in fighting against COVID-19.
  • |*Betacoronavirus/drug effects/genetics/immunology[MESH]
  • |Administration, Intranasal[MESH]
  • |Antiviral Agents/administration & dosage[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Coronavirus Infections/epidemiology/immunology/prevention & control/*therapy[MESH]
  • |Drug Delivery Systems/methods[MESH]
  • |Humans[MESH]
  • |Nanoparticles/administration & dosage/chemistry/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/immunology/*therapy[MESH]
  • |RNA, Small Interfering/administration & dosage/genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Theranostic Nanomedicine/*methods[MESH]
  • |Vaccines, Virus-Like Particle/administration & dosage[MESH]
  • |Viral Vaccines/administration & dosage/immunology[MESH]


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