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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Reumatol+Clin+(Engl+Ed) 2021 ; 17 (6): 309-312 Nephropedia Template TP
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Propuesta de uso de anakinra en el distres respiratorio agudo secundario a COVID-19 #MMPMID32482538
Munoz-Jimenez A; Rubio-Romero E; Marenco de la Fuente JL
Reumatol Clin (Engl Ed) 2021[Jun]; 17 (6): 309-312 PMID32482538show ga
The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS). This process is an inflammatory picture, involving an NLRP3 INFLAMOSOME-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. ANAKINRA is a potent biological drug, capable of blocking this IL 1 beta. We propose its use in controlling ARDS secondary to COVID-19 infection.