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10.1016/j.arcmed.2020.05.009

http://scihub22266oqcxt.onion/10.1016/j.arcmed.2020.05.009
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32482373!7241374!32482373
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suck abstract from ncbi


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pmid32482373      Arch+Med+Res 2020 ; 51 (6): 595-597
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  • Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19 #MMPMID32482373
  • Saha A; Sharma AR; Bhattacharya M; Sharma G; Lee SS; Chakraborty C
  • Arch Med Res 2020[Aug]; 51 (6): 595-597 PMID32482373show ga
  • Presently, we need more therapeutic molecules for this COVID-19 outbreak. The severity and mortality of the disease is associated with a high level of release of cytokine in the patients which is known as CRS (cytokine release syndrome) or cytokine storm syndrome. IL-6 is a type of pro-inflammatory cytokine which release in the severe COVID-19 patients. This cytokine initiates CRS the JAK-STAT or MAPK/NF-kappaB-IL-6 pathway. Tocilizumab, a humanized monoclonal antibody, is designed to bind both mIL-6R (membrane bound receptor for IL-6) and sIL-6R (soluble receptor for IL-6) and inhibit the JAK-STAT or MAPK/NF-kappaB-IL-6 signaling pathway. It finally stops the cytokine storm syndrome. However, we need to understand that how tocilizumab is bound with mIL-6R or sIL-6R. Similarly, we also need to understand more about the real molecular mechanism of activity of tocilizumab.
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Cytokine Release Syndrome/*drug therapy[MESH]
  • |Humans[MESH]
  • |Interleukin-6/immunology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Protein Binding[MESH]
  • |Receptors, Interleukin-6/*antagonists & inhibitors[MESH]
  • |SARS-CoV-2[MESH]


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