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10.1016/j.jaad.2020.05.109

http://scihub22266oqcxt.onion/10.1016/j.jaad.2020.05.109
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suck abstract from ncbi


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pmid32479979      J+Am+Acad+Dermatol 2020 ; 83 (2): 486-492
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  • Pernio-like skin lesions associated with COVID-19: A case series of 318 patients from 8 countries #MMPMID32479979
  • Freeman EE; McMahon DE; Lipoff JB; Rosenbach M; Kovarik C; Takeshita J; French LE; Thiers BH; Hruza GJ; Fox LP
  • J Am Acad Dermatol 2020[Aug]; 83 (2): 486-492 PMID32479979show ga
  • BACKGROUND: Increasing evidence suggests pernio-like lesions are cutaneous manifestations of coronavirus infectious disease 2019 (COVID-19). OBJECTIVE: To describe clinical and pathologic findings of pernio-like lesions in patients with confirmed or suspected COVID-19. METHODS: An international dermatology registry was circulated to health care providers worldwide through the American Academy of Dermatology, International League of Dermatologic Societies, and other organizations. RESULTS: We documented 505 patients with dermatologic manifestations associated with COVID-19, including 318 (63%) with pernio-like lesions. Patients with pernio-like lesions were generally young and healthy, with relatively mild COVID-19. Of 318 patients with confirmed or suspected COVID-19 by providers, 23 (7%) were laboratory-confirmed COVID-19 positive, and 20 others (6%) were close contacts of patients with confirmed COVID-19. Given current testing criteria, many patients lacked COVID-19 testing access. For 55% of patients, pernio-like lesions were their only symptom. In patients with other COVID-19 symptoms, pernio-like lesions typically appeared after other symptoms. Pernio-like lesions lasted a median of 14 days (interquartile range, 10-21 days). LIMITATIONS: A case series cannot estimate population-level incidence or prevalence. In addition, there may be confirmation bias in reporting. We cannot exclude an epiphenomenon. CONCLUSIONS: Pernio-like skin changes of the feet and hands, without another explanation, may suggest COVID-19 infection and should prompt confirmatory testing.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |Bias[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Chilblains/diagnosis/epidemiology/*virology[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/*complications/diagnosis/virology[MESH]
  • |Female[MESH]
  • |Foot[MESH]
  • |Hand[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnosis/virology[MESH]
  • |Registries/statistics & numerical data[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Skin Diseases/diagnosis/epidemiology/*virology[MESH]
  • |Time Factors[MESH]


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