Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cell.2020.05.006 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.05.006 32479746!7205692!32479746     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 181 (7): 1475-1488.e12 Nephropedia Template TP {{tp|p=32479746|t=2020. Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients |pdf=|usr=}}{{32479746}} gab.com Text Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32479746 #FOAvip Viruses are a constant threat to global health as highlighted by the current COVID-19 pandemic. Currently, lack of data underlying how the human host interacts with viruses, including the SARS-CoV-2 virus, limits effective therapeutic intervention. We introduce Viral-Track, a computational method that globally scans unmapped single-cell RNA sequencing (scRNA-seq) data for the presence of viral RNA, enabling transcriptional cell sorting of infected versus bystander cells. We demonstrate the sensitivity and specificity of Viral-Track to systematically detect viruses from multiple models of infection, including hepatitis B virus, in an unsupervised manner. Applying Viral-Track to bronchoalveloar-lavage samples from severe and mild COVID-19 patients reveals a dramatic impact of the virus on the immune system of severe patients compared to mild cases. Viral-Track detects an unexpected co-infection of the human metapneumovirus, present mainly in monocytes perturbed in type-I interferon (IFN)-signaling. Viral-Track provides a robust technology for dissecting the mechanisms of viral-infection and pathology. Twit Text FOAVip Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32479746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32479746 #FOAvip English Wikipedia <ref>{{Cite pmid|32479746}}</ref> Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients #MMPMID32479746 Bost P; Giladi A; Liu Y; Bendjelal Y; Xu G; David E; Blecher-Gonen R; Cohen M; Medaglia C; Li H; Deczkowska A; Zhang S; Schwikowski B; Zhang Z; Amit I Cell 2020[Jun]; 181 (7): 1475-1488.e12 PMID32479746show ga Viruses are a constant threat to global health as highlighted by the current COVID-19 pandemic. Currently, lack of data underlying how the human host interacts with viruses, including the SARS-CoV-2 virus, limits effective therapeutic intervention. We introduce Viral-Track, a computational method that globally scans unmapped single-cell RNA sequencing (scRNA-seq) data for the presence of viral RNA, enabling transcriptional cell sorting of infected versus bystander cells. We demonstrate the sensitivity and specificity of Viral-Track to systematically detect viruses from multiple models of infection, including hepatitis B virus, in an unsupervised manner. Applying Viral-Track to bronchoalveloar-lavage samples from severe and mild COVID-19 patients reveals a dramatic impact of the virus on the immune system of severe patients compared to mild cases. Viral-Track detects an unexpected co-infection of the human metapneumovirus, present mainly in monocytes perturbed in type-I interferon (IFN)-signaling. Viral-Track provides a robust technology for dissecting the mechanisms of viral-infection and pathology. |*Host-Pathogen Interactions[MESH] |*Software[MESH] |Animals[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Coinfection/immunology[MESH] |Coronavirus Infections/immunology/pathology/*physiopathology/virology[MESH] |Humans[MESH] |Interferons/immunology[MESH] |Lung/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/pathology/*physiopathology/virology[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH] |Sequence Analysis, RNA[MESH] |Severity of Illness Index[MESH]Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patient(epmc).pdf DeepDyve Pubget Overpricing