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10.7883/yoken.JJID.2020.165

http://scihub22266oqcxt.onion/10.7883/yoken.JJID.2020.165
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32475877!ä!32475877

suck abstract from ncbi


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pmid32475877      Jpn+J+Infect+Dis 2020 ; 73 (6): 399-403
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  • The Potential Transmission of SARS-CoV-2 from Patients with Negative RT-PCR Swab Tests to Others: Two Related Clusters of COVID-19 Outbreak #MMPMID32475877
  • Cao G; Tang S; Yang D; Shi W; Wang X; Wang H; Li C; Wei J; Ma L
  • Jpn J Infect Dis 2020[Nov]; 73 (6): 399-403 PMID32475877show ga
  • In December 2019, a cluster of cases of acute respiratory illness, novel coronavirus-infected pneumonia, occurred in Wuhan, Hubei Province, China. The false-negative nasopharyngeal swabs for SARS-CoV-2 caused delayed diagnosis of COVID-19, which hindered the prevention and control of the pandemic. The transmission risk of SARS-CoV-2 in negative nasopharyngeal swabs cases has rarely been addressed previously. This study evaluated two clusters of COVID-19 in six patients, four of whom (66.7%) tested negative for RNA of SARS-CoV-2 on RT-PCR of nasopharyngeal swabs. All epidemiological, clinical, and laboratory data were collected. The first cluster was a nosocomial infection of four health care providers in early January. One case resulted in a sequential familial cluster of infection. All patients either self-quarantined at home or were admitted to hospital for isolated treatment. All recovered and were anti-SARS-CoV-2 IgG- and/or IgM-positive (100%) for serological detection of SARS-CoV-2 at the recovery stage. Our study provides a cautionary warning that negative results for nasopharyngeal swabs of suspected SARS-CoV-2 infection can increase the risk of nosocomial infection among health care providers. Serologic detection for anti-SARS-CoV-2 IgG and/or IgM is an important test in the diagnosis of COVID-19.
  • |*Disease Outbreaks[MESH]
  • |*Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis/epidemiology/prevention & control/*transmission[MESH]
  • |China/epidemiology[MESH]
  • |Cross Infection[MESH]
  • |False Negative Reactions[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Retrospective Studies[MESH]


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