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10.1080/13543784.2020.1777277 http://scihub22266oqcxt.onion/10.1080/13543784.2020.1777277 32475183!7441752!32475183     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Opin+Investig+Drugs 2020 ; 29 (8): 793-796 Nephropedia Template TP {{tp|p=32475183|t=2020. Does lopinavir measure up in the treatment of COVID-19?|pdf=|usr=}}{{32475183}} gab.com Text Does lopinavir measure up in the treatment of COVID-19 JO: Expert Opin Investig Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32475183 #FOAvip INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomized trial in hospitalized subjects with COVID-9 in a respiratory sample and pneumonia. As, in severe COVID-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this combination should not be used at this stage of COVID-19. EXPERT OPINION: In my opinion, the rationale for undertaking a trial of lopinavir/ritonavir in COVID-19 was poor. The analysis of a modified intention to treat group analysis in LOTUS China may have introduced bias. After LOTUS China, there is probably no future for lopinavir in the treatment of severe COVID-19, but some clinical trials for prevention or in various stages of COVID-19 have recently started or are ongoing. The major limitation of these trials is that as lopinavir does not inhibit COVID-19, it is unlikely to prevent infection, reduce viral load, or reduce the severity. However, these trials may be worthwhile in finally determining whether lopinavir has any role in preventing or treating COVID-19. Twit Text FOAVip Does lopinavir measure up in the treatment of COVID-19 ????Expert Opin Investig Drugs http://www.kidney.de/pget.php?&tw=1&pmid=32475183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32475183 #FOAvip English Wikipedia <ref>{{Cite pmid|32475183}}</ref> Does lopinavir measure up in the treatment of COVID-19? #MMPMID32475183 Doggrell SA Expert Opin Investig Drugs 2020[Aug]; 29 (8): 793-796 PMID32475183show ga INTRODUCTION: Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. AREAS COVERED: This evaluation is of LOTUS China (the Lopinavir Trial for Suppression of SARS-Cov-2 in China), which was a randomized trial in hospitalized subjects with COVID-9 in a respiratory sample and pneumonia. As, in severe COVID-19, lopinavir/ritonavir had no beneficial effects but increased gastrointestinal adverse effects, this combination should not be used at this stage of COVID-19. EXPERT OPINION: In my opinion, the rationale for undertaking a trial of lopinavir/ritonavir in COVID-19 was poor. The analysis of a modified intention to treat group analysis in LOTUS China may have introduced bias. After LOTUS China, there is probably no future for lopinavir in the treatment of severe COVID-19, but some clinical trials for prevention or in various stages of COVID-19 have recently started or are ongoing. The major limitation of these trials is that as lopinavir does not inhibit COVID-19, it is unlikely to prevent infection, reduce viral load, or reduce the severity. However, these trials may be worthwhile in finally determining whether lopinavir has any role in preventing or treating COVID-19. |Antiviral Agents/*administration & dosage/pharmacology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Drug Combinations[MESH] |Humans[MESH] |Lopinavir/*administration & dosage/pharmacology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |Randomized Controlled Trials as Topic[MESH] |Ritonavir/*administration & dosage/pharmacology[MESH] |Severity of Illness Index[MESH] |Treatment Outcome[MESH]Does lopinavir measure up in the treatment of COVID-19?(epmc).pdf DeepDyve Pubget Overpricing