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10.1016/j.jmii.2020.05.014

http://scihub22266oqcxt.onion/10.1016/j.jmii.2020.05.014
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32474026!7247474!32474026
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suck abstract from ncbi


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pmid32474026      J+Microbiol+Immunol+Infect 2020 ; 53 (5): 674-675
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  • Lopinavir/ritonavir use in Covid-19 infection: is it completely non-beneficial? #MMPMID32474026
  • Owa AB; Owa OT
  • J Microbiol Immunol Infect 2020[Oct]; 53 (5): 674-675 PMID32474026show ga
  • Covid-19 infection caused by the novel coronavirus SARS-COV-2 continues to be a major global health challenge. Till date, no drug has been approved for the treatment of this infection. A number of medications have been proposed and there are ongoing clinical trials around the world to find a suitable treatment. A recent randomised control trial compared lopinavir/ritonavir with standard care among 199 patients with severe Covid-19 infection and concluded that there was no significant reduction in mortality rate with lopinavir/ritonavir. However, there are a few important lessons which may be learnt from the study apart from the statistical reduction in mortality rate. There was a numerical reduction in mortality rate, less intensive care unit stay and less complications in the lopinavir-ritonavir group. This article points out some of those important lessons with some suggestions for future clinical trials.
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/mortality[MESH]
  • |Drug Combinations[MESH]
  • |Drug Resistance, Viral/physiology[MESH]
  • |Humans[MESH]
  • |Lopinavir/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/mortality[MESH]
  • |Ritonavir/*therapeutic use[MESH]


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