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10.1016/j.jinf.2020.05.046

http://scihub22266oqcxt.onion/10.1016/j.jinf.2020.05.046
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32473235!7255350!32473235
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suck abstract from ncbi


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pmid32473235      J+Infect 2020 ; 81 (2): 266-275
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  • Co-infections in people with COVID-19: a systematic review and meta-analysis #MMPMID32473235
  • Lansbury L; Lim B; Baskaran V; Lim WS
  • J Infect 2020[Aug]; 81 (2): 266-275 PMID32473235show ga
  • OBJECTIVES: In previous influenza pandemics, bacterial co-infections have been a major cause of mortality. We aimed to evaluate the burden of co-infections in patients with COVID-19. METHODS: We systematically searched Embase, Medline, Cochrane Library, LILACS and CINAHL for eligible studies published from 1 January 2020 to 17 April 2020. We included patients of all ages, in all settings. The main outcome was the proportion of patients with a bacterial, fungal or viral co-infection. . RESULTS: Thirty studies including 3834 patients were included. Overall, 7% of hospitalised COVID-19 patients had a bacterial co-infection (95% CI 3-12%, n=2183, I(2)=92.2%). A higher proportion of ICU patients had bacterial co-infections than patients in mixed ward/ICU settings (14%, 95% CI 5-26, I(2)=74.7% versus 4%, 95% CI 1-9, I(2)= 91.7%). The commonest bacteria were Mycoplasma pneumonia, Pseudomonas aeruginosa and Haemophilus influenzae. The pooled proportion with a viral co-infection was 3% (95% CI 1-6, n=1014, I(2)=62.3%), with Respiratory Syncytial Virus and influenza A the commonest. Three studies reported fungal co-infections. CONCLUSIONS: A low proportion of COVID-19 patients have a bacterial co-infection; less than in previous influenza pandemics. These findings do not support the routine use of antibiotics in the management of confirmed COVID-19 infection.
  • |Bacterial Infections/complications/epidemiology/*virology[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coinfection/epidemiology/*microbiology/*virology[MESH]
  • |Coronavirus Infections/complications/epidemiology/*virology[MESH]
  • |Humans[MESH]
  • |Mycoses/complications/epidemiology/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/epidemiology/*virology[MESH]
  • |SARS-CoV-2[MESH]


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