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10.1093/jac/dkaa191

http://scihub22266oqcxt.onion/10.1093/jac/dkaa191
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32473020!7314033!32473020
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suck abstract from ncbi


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pmid32473020      J+Antimicrob+Chemother 2020 ; 75 (9): 2376-2380
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  • Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial #MMPMID32473020
  • Le MP; Peiffer-Smadja N; Guedj J; Neant N; Mentre F; Ader F; Yazdanpanah Y; Peytavin G
  • J Antimicrob Chemother 2020[Sep]; 75 (9): 2376-2380 PMID32473020show ga
  • Around the world, several dose regimens of hydroxychloroquine have been used for COVID-19 infection treatment, with the objective of identifying a short-term course. Hydroxychloroquine was found to decrease the viral replication in a concentration-dependent manner in vitro and to be more active when added prior to the viral challenge. A loading dose is used to rapidly attain a target drug concentration, which is usually considered as approximately the steady-state concentration. With a loading dose, the minimum effective concentration is reached much more rapidly than when using only the maintenance dose from the start. Thus, we propose a hydroxychloroquine sulphate dose regimen of 400 mg twice daily at Day 1 then 400 mg once daily from Day 2 to Day 10. We aim to evaluate this in the C-20-15 DisCoVeRy trial.
  • |*Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Clinical Trials as Topic/*methods[MESH]
  • |Coronavirus Infections/*drug therapy/metabolism[MESH]
  • |Drug Administration Schedule[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*administration & dosage[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/metabolism[MESH]


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