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10.1136/annrheumdis-2020-217871

http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-217871
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suck abstract from ncbi


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pmid32471903      Ann+Rheum+Dis 2020 ; 79 (7): 859-866
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  • Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry #MMPMID32471903
  • Gianfrancesco M; Hyrich KL; Al-Adely S; Carmona L; Danila MI; Gossec L; Izadi Z; Jacobsohn L; Katz P; Lawson-Tovey S; Mateus EF; Rush S; Schmajuk G; Simard J; Strangfeld A; Trupin L; Wysham KD; Bhana S; Costello W; Grainger R; Hausmann JS; Liew JW; Sirotich E; Sufka P; Wallace ZS; Yazdany J; Machado PM; Robinson PC
  • Ann Rheum Dis 2020[Jul]; 79 (7): 859-866 PMID32471903show ga
  • OBJECTIVES: COVID-19 outcomes in people with rheumatic diseases remain poorly understood. The aim was to examine demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease. METHODS: Case series of individuals with rheumatic disease and COVID-19 from the COVID-19 Global Rheumatology Alliance registry: 24 March 2020 to 20 April 2020. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities and rheumatic disease medications taken immediately prior to infection were analysed. RESULTS: A total of 600 cases from 40 countries were included. Nearly half of the cases were hospitalised (277, 46%) and 55 (9%) died. In multivariable-adjusted models, prednisone dose >/=10 mg/day was associated with higher odds of hospitalisation (OR 2.05, 95% CI 1.06 to 3.96). Use of conventional disease-modifying antirheumatic drug (DMARD) alone or in combination with biologics/Janus Kinase inhibitors was not associated with hospitalisation (OR 1.23, 95% CI 0.70 to 2.17 and OR 0.74, 95% CI 0.37 to 1.46, respectively). Non-steroidal anti-inflammatory drug (NSAID) use was not associated with hospitalisation status (OR 0.64, 95% CI 0.39 to 1.06). Tumour necrosis factor inhibitor (anti-TNF) use was associated with a reduced odds of hospitalisation (OR 0.40, 95% CI 0.19 to 0.81), while no association with antimalarial use (OR 0.94, 95% CI 0.57 to 1.57) was observed. CONCLUSIONS: We found that glucocorticoid exposure of >/=10 mg/day is associated with a higher odds of hospitalisation and anti-TNF with a decreased odds of hospitalisation in patients with rheumatic disease. Neither exposure to DMARDs nor NSAIDs were associated with increased odds of hospitalisation.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]
  • |Antimalarials/*therapeutic use[MESH]
  • |Antirheumatic Agents/*therapeutic use[MESH]
  • |Arthritis, Psoriatic/complications/drug therapy[MESH]
  • |Arthritis, Rheumatoid/complications/drug therapy[MESH]
  • |Betacoronavirus[MESH]
  • |Biological Products/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/complications/mortality/*therapy[MESH]
  • |Female[MESH]
  • |Glucocorticoids/*therapeutic use[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Janus Kinase Inhibitors/therapeutic use[MESH]
  • |Lupus Erythematosus, Systemic/complications/drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/mortality/*therapy[MESH]
  • |Prednisone/therapeutic use[MESH]
  • |Protective Factors[MESH]
  • |Registries[MESH]
  • |Rheumatic Diseases/complications/*drug therapy[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Spondylarthropathies/complications/drug therapy[MESH]
  • |Tumor Necrosis Factor Inhibitors/*therapeutic use[MESH]
  • |Vasculitis/complications/drug therapy[MESH]


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