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10.1080/22221751.2020.1760735 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1760735 32471334!7448924!32471334     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 1080-1091 Nephropedia Template TP {{tp|p=32471334|t=2020. Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV |pdf=|usr=}}{{32471334}} gab.com Text Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32471334 #FOAvip Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein horizontal line fusion peptide, heptad repeat 2, and receptor binding domain (RBD) horizontal line and tested their immunogenicity and protective capacity in rabbits. Using a "plug-and-display" SpyTag/SpyCatcher system, we coupled RBD to lumazine synthase (LS) particles producing multimeric RBD-presenting particles (RBD-LS). RBD-LS vaccination induced antibody responses of high magnitude and quality (avidity, MERS-CoV neutralizing capacity, and mucosal immunity) with cross-clade neutralization. The antibody responses were associated with blocking viral replication and upper and lower respiratory tract protection against MERS-CoV infection in rabbits. This arrayed multivalent presentation of the viral RBD using the antigen-SpyTag/LS-SpyCatcher is a promising MERS-CoV vaccine candidate and this platform may be applied for the rapid development of vaccines against other emerging viruses such as SARS-CoV-2. Twit Text FOAVip Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32471334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32471334 #FOAvip English Wikipedia <ref>{{Cite pmid|32471334}}</ref> Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV #MMPMID32471334 Okba NMA; Widjaja I; van Dieren B; Aebischer A; van Amerongen G; de Waal L; Stittelaar KJ; Schipper D; Martina B; van den Brand JMA; Beer M; Bosch BJ; Haagmans BL Emerg Microbes Infect 2020[Dec]; 9 (1): 1080-1091 PMID32471334show ga Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein horizontal line fusion peptide, heptad repeat 2, and receptor binding domain (RBD) horizontal line and tested their immunogenicity and protective capacity in rabbits. Using a "plug-and-display" SpyTag/SpyCatcher system, we coupled RBD to lumazine synthase (LS) particles producing multimeric RBD-presenting particles (RBD-LS). RBD-LS vaccination induced antibody responses of high magnitude and quality (avidity, MERS-CoV neutralizing capacity, and mucosal immunity) with cross-clade neutralization. The antibody responses were associated with blocking viral replication and upper and lower respiratory tract protection against MERS-CoV infection in rabbits. This arrayed multivalent presentation of the viral RBD using the antigen-SpyTag/LS-SpyCatcher is a promising MERS-CoV vaccine candidate and this platform may be applied for the rapid development of vaccines against other emerging viruses such as SARS-CoV-2. |*Antibody Formation[MESH] |*Antigen Presentation[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Antibody Affinity[MESH] |Binding Sites[MESH] |Coronavirus Infections/*immunology/prevention & control[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Genetic Vectors[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunogenicity, Vaccine[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology/physiology[MESH] |Neutralization Tests[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |Rabbits[MESH] |Spike Glycoprotein, Coronavirus/biosynthesis/*immunology[MESH] |Viral Vaccines/*immunology[MESH]Particulate multivalent presentation of the receptor binding domain in(epmc).pdf DeepDyve Pubget Overpricing