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10.3390/ijms21113812 http://scihub22266oqcxt.onion/10.3390/ijms21113812 32471278!7312074!32471278     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (11): ä Nephropedia Template TP {{tp|p=32471278|t=2020. Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 |pdf=|usr=}}{{32471278}} gab.com Text Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32471278 #FOAvip At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. COVID-19 pathology is characterized by extreme inflammation and amplified immune response with activation of a cytokine storm. A subsequent progression to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can take place, which is often followed by death. The causes of these strong inflammatory responses in SARS-CoV-2 infection are still unknown. As uncontrolled pulmonary inflammation is likely the main cause of death in SARS-CoV-2 infection, anti-inflammatory therapeutic interventions are particularly important. Fenretinide N-(4-hydroxyphenyl) retinamide is a bioactive molecule characterized by poly-pharmacological properties and a low toxicity profile. Fenretinide is endowed with antitumor, anti-inflammatory, antiviral, and immunomodulating properties other than efficacy in obesity/diabetic pathologies. Its anti-inflammatory and antiviral activities, in particular, could likely have utility in multimodal therapies for the treatment of ALI/ARDS in COVID-19 patients. Moreover, fenretinide administration by pulmonary delivery systems could further increase its therapeutic value by carrying high drug concentrations to the lungs and triggering a rapid onset of activity. This is particularly important in SARS-CoV-2 infection, where only a narrow time window exists for therapeutic intervention. Twit Text FOAVip Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32471278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32471278 #FOAvip English Wikipedia <ref>{{Cite pmid|32471278}}</ref> Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 #MMPMID32471278 Orienti I; Gentilomi GA; Farruggia G Int J Mol Sci 2020[May]; 21 (11): ä PMID32471278show ga At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. COVID-19 pathology is characterized by extreme inflammation and amplified immune response with activation of a cytokine storm. A subsequent progression to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can take place, which is often followed by death. The causes of these strong inflammatory responses in SARS-CoV-2 infection are still unknown. As uncontrolled pulmonary inflammation is likely the main cause of death in SARS-CoV-2 infection, anti-inflammatory therapeutic interventions are particularly important. Fenretinide N-(4-hydroxyphenyl) retinamide is a bioactive molecule characterized by poly-pharmacological properties and a low toxicity profile. Fenretinide is endowed with antitumor, anti-inflammatory, antiviral, and immunomodulating properties other than efficacy in obesity/diabetic pathologies. Its anti-inflammatory and antiviral activities, in particular, could likely have utility in multimodal therapies for the treatment of ALI/ARDS in COVID-19 patients. Moreover, fenretinide administration by pulmonary delivery systems could further increase its therapeutic value by carrying high drug concentrations to the lungs and triggering a rapid onset of activity. This is particularly important in SARS-CoV-2 infection, where only a narrow time window exists for therapeutic intervention. |Animals[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/pathology/virology[MESH] |Cytokines[MESH] |Fenretinide/pharmacology/*therapeutic use[MESH] |Humans[MESH] |Macrophages/cytology/drug effects/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/pathology/virology[MESH] |Respiratory System/drug effects/metabolism[MESH] |SARS-CoV-2[MESH]Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In CO(epmc).pdf DeepDyve Pubget Overpricing