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10.3390/ph13060107

http://scihub22266oqcxt.onion/10.3390/ph13060107
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32471171!7344896!32471171
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suck abstract from ncbi


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pmid32471171      Pharmaceuticals+(Basel) 2020 ; 13 (6): ä
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  • Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells #MMPMID32471171
  • Lehene M; Fischer-Fodor E; Scurtu F; Hadade ND; Gal E; Mot AC; Matei A; Silaghi-Dumitrescu R
  • Pharmaceuticals (Basel) 2020[May]; 13 (6): ä PMID32471171show ga
  • Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.
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