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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pharmaceuticals+(Basel) 2020 ; 13 (6): ä Nephropedia Template TP
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Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells #MMPMID32471171
Lehene M; Fischer-Fodor E; Scurtu F; Hadade ND; Gal E; Mot AC; Matei A; Silaghi-Dumitrescu R
Pharmaceuticals (Basel) 2020[May]; 13 (6): ä PMID32471171show ga
Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. It also degrades hemoglobin in intact blood or in isolated erythrocytes. The survival rates and metabolic activities of several leukocyte subsets implicated in the antiviral cellular immune response are also affected. Excess ascorbate is thus an unselective biological stress agent.