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10.1016/j.ijid.2020.05.068

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.05.068
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32470606!7250072!32470606
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suck abstract from ncbi


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pmid32470606      Int+J+Infect+Dis 2020 ; 96 (ä): 683-687
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  • Clinical characteristics of critically ill patients co-infected with SARS-CoV-2 and the influenza virus in Wuhan, China #MMPMID32470606
  • Ma S; Lai X; Chen Z; Tu S; Qin K
  • Int J Infect Dis 2020[Jul]; 96 (ä): 683-687 PMID32470606show ga
  • OBJECTIVE: To delineate the clinical characteristics of critically ill COVID-19 patients co-infected with influenza. METHODS: This study included adult patients with laboratory-confirmed COVID-19 form Tongji Hospital (Wuhan, China), with or without influenza, and compared their clinical characteristics. RESULTS: Among 93 patients, 44 died and 49 were discharged. Forty-four (47.3%) were infected with influenza virus A and two (2.2%) with influenza virus B. Twenty-two (50.0%) of the non-survivors and 24 (49.0%) of the survivors were infected with the influenza virus. Critically ill COVID-19 patients with influenza were more prone to cardiac injury than those without influenza. For the laboratory indicators at admission the following were higher in non-survivors with influenza than in those without influenza: white blood cell counts, neutrophil counts, levels of tumor necrosis factor-alpha, D-dimer value, and proportion of elevated creatinine. CONCLUSION: The results showed that a high proportion of COVID-19 patients were co-infected with influenza in Tongji Hospital, with no significant difference in the proportion of co-infection between survivors and non-survivors. The critically ill COVID-19 patients with influenza exhibited more severe inflammation and organ injury, indicating that co-infection with the influenza virus may induce an earlier and more frequently occurring cytokine storm.
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coinfection/*virology[MESH]
  • |Coronavirus Infections/complications/*diagnosis[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Influenza, Human/complications/*diagnosis[MESH]
  • |Leukocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*diagnosis[MESH]
  • |SARS-CoV-2[MESH]


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