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10.1002/jmv.26087 http://scihub22266oqcxt.onion/10.1002/jmv.26087 32470148!7283867!32470148     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (10): 2216-2220 Nephropedia Template TP {{tp|p=32470148|t=2020. Serum KL-6 concentrations as a novel biomarker of severe COVID-19 |pdf=|usr=}}{{32470148}} gab.com Text Serum KL-6 concentrations as a novel biomarker of severe COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32470148 #FOAvip Severe acute respiratory syndrome coronavirus 2-induced direct cytopathic effects against type I and II pneumocytes mediate lung damage. Krebs von den Lungen-6 (KL-6) is mainly produced by damaged or regenerating alveolar type II pneumocytes. This preliminary study analyzed serum concentrations of KL-6 in patients with coronavirus disease (COVID-19) to verify its potential as a prognostic biomarker of severity. Twenty-two patients (median age [interquartile range] 63 [59-68] years, 16 males) with COVID-19 were enrolled prospectively. Patients were divided into mild-moderate and severe groups, according to respiratory impairment and clinical management. KL-6 serum concentrations and lymphocyte subset were obtained. Peripheral natural killer (NK) cells/microL were significantly higher in nonsevere patients than in the severe group (P = .0449) and the best cut-off value was 119 cells/microL. KL-6 serum concentrations were significantly higher in severe patients than the nonsevere group (P = .0118). Receiver operating characteristic analysis distinguished severe and nonsevere patients according to KL-6 serum levels and the best cut-off value was 406.5 U/mL. NK cell analysis and assay of KL-6 in serum can help identify severe COVID-19 patients. Increased KL-6 serum concentrations were observed in patients with severe pulmonary involvement, revealing a prognostic value and supporting the potential usefulness of KL-6 measurement to evaluate COVID-19 patients' prognosis. Twit Text FOAVip Serum KL-6 concentrations as a novel biomarker of severe COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32470148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32470148 #FOAvip English Wikipedia <ref>{{Cite pmid|32470148}}</ref> Serum KL-6 concentrations as a novel biomarker of severe COVID-19 #MMPMID32470148 d'Alessandro M; Cameli P; Refini RM; Bergantini L; Alonzi V; Lanzarone N; Bennett D; Rana GD; Montagnani F; Scolletta S; Franchi F; Frediani B; Valente S; Mazzei MA; Bonella F; Bargagli E J Med Virol 2020[Oct]; 92 (10): 2216-2220 PMID32470148show ga Severe acute respiratory syndrome coronavirus 2-induced direct cytopathic effects against type I and II pneumocytes mediate lung damage. Krebs von den Lungen-6 (KL-6) is mainly produced by damaged or regenerating alveolar type II pneumocytes. This preliminary study analyzed serum concentrations of KL-6 in patients with coronavirus disease (COVID-19) to verify its potential as a prognostic biomarker of severity. Twenty-two patients (median age [interquartile range] 63 [59-68] years, 16 males) with COVID-19 were enrolled prospectively. Patients were divided into mild-moderate and severe groups, according to respiratory impairment and clinical management. KL-6 serum concentrations and lymphocyte subset were obtained. Peripheral natural killer (NK) cells/microL were significantly higher in nonsevere patients than in the severe group (P = .0449) and the best cut-off value was 119 cells/microL. KL-6 serum concentrations were significantly higher in severe patients than the nonsevere group (P = .0118). Receiver operating characteristic analysis distinguished severe and nonsevere patients according to KL-6 serum levels and the best cut-off value was 406.5 U/mL. NK cell analysis and assay of KL-6 in serum can help identify severe COVID-19 patients. Increased KL-6 serum concentrations were observed in patients with severe pulmonary involvement, revealing a prognostic value and supporting the potential usefulness of KL-6 measurement to evaluate COVID-19 patients' prognosis. |Aged[MESH] |Biomarkers/*blood[MESH] |COVID-19/*blood/*diagnosis/immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Killer Cells, Natural/immunology/virology[MESH] |Lung/immunology/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Mucin-1/*blood[MESH] |Pandemics[MESH] |Prognosis[MESH] |ROC Curve[MESH]Serum KL-6 concentrations as a novel biomarker of severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing