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10.1111/dom.14099

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suck abstract from ncbi


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pmid32469464      Diabetes+Obes+Metab 2020 ; 22 (10): 1897-1906
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  • Newly diagnosed diabetes is associated with a higher risk of mortality than known diabetes in hospitalized patients with COVID-19 #MMPMID32469464
  • Li H; Tian S; Chen T; Cui Z; Shi N; Zhong X; Qiu K; Zhang J; Zeng T; Chen L; Zheng J
  • Diabetes Obes Metab 2020[Oct]; 22 (10): 1897-1906 PMID32469464show ga
  • AIM: To evaluate the association between different degrees of hyperglycaemia and the risk of all-cause mortality among hospitalized patients with COVID-19. MATERIALS AND METHODS: In a retrospective study conducted from 22 January to 17 March 2020, 453 patients were admitted to Union Hospital in Wuhan, China, with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection. Patients were classified into four categories: normal glucose, hyperglycaemia (fasting glucose 5.6-6.9 mmol/L and/or HbA1c 5.7%-6.4%), newly diagnosed diabetes (fasting glucose >/=7 mmol/L and/or HbA1c >/=6.5%) and known diabetes. The major outcomes included in-hospital mortality, intensive care unit (ICU) admission and invasive mechanical ventilation (IMV). RESULTS: Patients with newly diagnosed diabetes constituted the highest percentage to be admitted to the ICU (11.7%) and require IMV (11.7%), followed by patients with known diabetes (4.1%; 9.2%) and patients with hyperglycaemia (6.2%; 4.7%), compared with patients with normal glucose (1.5%; 2.3%), respectively. The multivariable-adjusted hazard ratios of mortality among COVID-19 patients with normal glucose, hyperglycaemia, newly diagnosed diabetes and known diabetes were 1.00, 3.29 (95% confidence interval [CI] 0.65-16.6), 9.42 (95% CI 2.18-40.7) and 4.63 (95% CI 1.02-21.0), respectively. CONCLUSION: We showed that COVID-19 patients with newly diagnosed diabetes had the highest risk of all-cause mortality compared with COVID-19 patients with known diabetes, hyperglycaemia and normal glucose. Patients with COVID-19 need to be kept under surveillance for blood glucose screening.
  • |Aged[MESH]
  • |Asymptomatic Diseases/*mortality/therapy[MESH]
  • |Blood Glucose/physiology[MESH]
  • |COVID-19/complications/epidemiology/*mortality/*therapy[MESH]
  • |China/epidemiology[MESH]
  • |Diabetes Mellitus/diagnosis/*mortality/*therapy[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hyperglycemia/complications/diagnosis/mortality/therapy[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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