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10.1111/apha.13513 http://scihub22266oqcxt.onion/10.1111/apha.13513 32469114!7267104!32469114     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Physiol+(Oxf) 2021 ; 231 (1): e13513 Nephropedia Template TP {{tp|p=32469114|t=2021. An update on ACE2 amplification and its therapeutic potential |pdf=|usr=}}{{32469114}} gab.com Text An update on ACE2 amplification and its therapeutic potential JO: Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=32469114 #FOAvip The renin angiotensin system (RAS) plays an important role in the pathogenesis of variety of diseases. Targeting the formation and action of angiotensin II (Ang II), the main RAS peptide, has been the key therapeutic target for last three decades. ACE-related carboxypeptidase (ACE2), a monocarboxypeptidase that had been discovered 20 years ago, is one of the catalytically most potent enzymes known to degrade Ang II to Ang-(1-7), a peptide that is increasingly accepted to have organ-protective properties that oppose and counterbalance those of Ang II. In addition to its role as a RAS enzyme ACE2 is the main receptor for SARS-CoV-2. In this review, we discuss various strategies that have been used to achieve amplification of ACE2 activity including the potential therapeutic potential of soluble recombinant ACE2 protein and novel shorter ACE2 variants. Twit Text FOAVip An update on ACE2 amplification and its therapeutic potential ????Acta Physiol (Oxf) http://www.kidney.de/pget.php?&tw=1&pmid=32469114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32469114 #FOAvip English Wikipedia <ref>{{Cite pmid|32469114}}</ref> An update on ACE2 amplification and its therapeutic potential #MMPMID32469114 Marquez A; Wysocki J; Pandit J; Batlle D Acta Physiol (Oxf) 2021[Jan]; 231 (1): e13513 PMID32469114show ga The renin angiotensin system (RAS) plays an important role in the pathogenesis of variety of diseases. Targeting the formation and action of angiotensin II (Ang II), the main RAS peptide, has been the key therapeutic target for last three decades. ACE-related carboxypeptidase (ACE2), a monocarboxypeptidase that had been discovered 20 years ago, is one of the catalytically most potent enzymes known to degrade Ang II to Ang-(1-7), a peptide that is increasingly accepted to have organ-protective properties that oppose and counterbalance those of Ang II. In addition to its role as a RAS enzyme ACE2 is the main receptor for SARS-CoV-2. In this review, we discuss various strategies that have been used to achieve amplification of ACE2 activity including the potential therapeutic potential of soluble recombinant ACE2 protein and novel shorter ACE2 variants. |*Angiotensin-Converting Enzyme 2/genetics/metabolism/therapeutic use[MESH] |*COVID-19 Drug Treatment[MESH] |*Genetic Therapy[MESH] |*Receptors, Virus/genetics/metabolism/therapeutic use[MESH] |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19/enzymology/genetics/*therapy/virology[MESH] |Enzyme Activation[MESH] |Enzyme Activators/therapeutic use[MESH] |Gene Amplification[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Recombinant Proteins/therapeutic use[MESH] |SARS-CoV-2/*pathogenicity[MESH]An update on ACE2 amplification and its therapeutic potential (epmc).pdf DeepDyve Pubget Overpricing