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10.1007/s40261-020-00927-1

http://scihub22266oqcxt.onion/10.1007/s40261-020-00927-1
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32468425!7255448!32468425
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suck abstract from ncbi


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pmid32468425      Clin+Drug+Investig 2020 ; 40 (7): 591-601
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  • An Updated Systematic Review of the Therapeutic Role of Hydroxychloroquine in Coronavirus Disease-19 (COVID-19) #MMPMID32468425
  • Das S; Bhowmick S; Tiwari S; Sen S
  • Clin Drug Investig 2020[Jul]; 40 (7): 591-601 PMID32468425show ga
  • BACKGROUND AND OBJECTIVE: The world is currently experiencing the Coronavirus Disease-19 (COVID-19) pandemic. There is no approved drug for the definitive treatment of the disease. Various drugs are being tried for the treatment of COVID-19, including hydroxychloroquine (HCQ). This study was performed to systematically review the therapeutic role of HCQ in COVID-19 from the available literature. METHODS: PubMed, Embase, ClinicalTrials.gov, ICTRP (WHO), Cochrane Library databases, and two pre-print servers (medRxiv.org and Research Square) were searched for clinical studies that evaluated the therapeutic role of HCQ on COVID-19 until 10 May 2020. The available studies were critically analyzed and the data were extracted. RESULTS: A total of 663 articles were screened and 12 clinical studies (seven peer-reviewed and published studies and five non-peer-reviewed studies from pre-print servers) with a total sample size of 3543 patients were included. Some of the clinical studies demonstrated good virological and clinical outcomes with HCQ alone or in combination with azithromycin in COVID-19 patients, although the studies had major methodological limitations. Some of the other studies showed negative results with HCQ therapy along with the risk of adverse reactions. CONCLUSION: The results of efficacy and safety of HCQ in COVID-19, as obtained from the clinical studies, are not satisfactory, although many of these studies had major methodological limitations. Stronger evidence from well-designed robust randomized clinical trials is required before conclusively determining the role of HCQ in the treatment of COVID-19. Clinical prudence is required in advocating HCQ as a therapeutic armamentarium in COVID-19.
  • |Animals[MESH]
  • |Anti-Bacterial Agents/therapeutic use[MESH]
  • |Azithromycin/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/adverse effects/*therapeutic use[MESH]
  • |Pandemics[MESH]


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