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10.1007/s00011-020-01366-6

http://scihub22266oqcxt.onion/10.1007/s00011-020-01366-6
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32468151!8823100!32468151
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suck abstract from ncbi


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pmid32468151      Inflamm+Res 2020 ; 69 (8): 757-763
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  • The unleashing of the immune system in COVID-19 and sepsis: the calm before the storm? #MMPMID32468151
  • Bellinvia S; Edwards CJ; Schisano M; Banfi P; Fallico M; Murabito P
  • Inflamm Res 2020[Aug]; 69 (8): 757-763 PMID32468151show ga
  • The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sorely testing health care systems and economies around the world and is rightly considered as the major health emergency in a century. Despite the course of the disease appearing to be mild in many cases, a significant proportion of symptomatic patients develop pneumonia requiring hospitalisation or progress to manifest respiratory complications leading to intensive care treatment. Potential interventions for SARS-CoV2-associated pneumonia are being tested, some of which holding promise, but as of today none of these has yet demonstrated outstanding efficacy in treating COVID-19. In this article, we discuss fresh perspectives and insights into the potential role of immune dysregulation in COVID-19 as well as similarities with systemic inflammatory response in sepsis and the rationale for exploring novel treatment options affecting host immune response.
  • |Betacoronavirus[MESH]
  • |Biomarkers[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/complications/*diagnosis/*immunology/therapy[MESH]
  • |Cytokine Release Syndrome/virology[MESH]
  • |Cytokines/immunology[MESH]
  • |Humans[MESH]
  • |Immune System/*virology[MESH]
  • |Immunity, Innate[MESH]
  • |Inflammation[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*diagnosis/*immunology/therapy[MESH]
  • |SARS-CoV-2[MESH]


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