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10.3892/ijmm.2020.4608 http://scihub22266oqcxt.onion/10.3892/ijmm.2020.4608 32468014!7307820!32468014     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32468014.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2020 ; 46 (2): 467-488 Nephropedia Template TP {{tp|p=32468014|t=2020. Comprehensive analysis of drugs to treat SARS?CoV?2 infection: Mechanistic insights into current COVID?19 therapies (Review) |pdf=|usr=}}{{32468014}} gab.com Text Comprehensive analysis of drugs to treat SARS CoV 2 infection: Mechanistic insights into current COVID 19 therapies (Review) JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32468014 #FOAvip The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID?19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID?19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts. Twit Text FOAVip Comprehensive analysis of drugs to treat SARS CoV 2 infection: Mechanistic insights into current COVID 19 therapies (Review) ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=32468014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32468014 #FOAvip English Wikipedia <ref>{{Cite pmid|32468014}}</ref> Comprehensive analysis of drugs to treat SARS?CoV?2 infection: Mechanistic insights into current COVID?19 therapies (Review) #MMPMID32468014 Nitulescu GM; Paunescu H; Moschos SA; Petrakis D; Nitulescu G; Ion GND; Spandidos DA; Nikolouzakis TK; Drakoulis N; Tsatsakis A Int J Mol Med 2020[Aug]; 46 (2): 467-488 PMID32468014show ga The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID?19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID?19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts. |*Drug Repositioning/methods/standards/trends[MESH] |Angiotensin II Type 1 Receptor Blockers/classification/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*drug effects/pathogenicity/physiology[MESH] |Bromhexine/pharmacology/therapeutic use[MESH] |COVID-19[MESH] |Chlorpromazine/pharmacology/therapeutic use[MESH] |Clinical Trials as Topic/methods[MESH] |Coronavirus Infections/*drug therapy/epidemiology/mortality[MESH] |Diminazene/pharmacology/therapeutic use[MESH] |Esters[MESH] |Gabexate/analogs & derivatives/pharmacology/therapeutic use[MESH] |Guanidines[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism/therapeutic use[MESH] |Pneumonia, Viral/*drug therapy/epidemiology/mortality[MESH] |Receptor, Angiotensin, Type 1/metabolism[MESH] |Recombinant Proteins/chemistry/therapeutic use[MESH] |SARS-CoV-2[MESH] |Signal Transduction/drug effects[MESH]Comprehensive analysis of drugs to treat SARS?CoV?2 infection: Mechani(epmc).pdf DeepDyve Pubget Overpricing