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10.3390/ijms21103708

http://scihub22266oqcxt.onion/10.3390/ijms21103708
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32466119!7279303!32466119
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suck abstract from ncbi


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pmid32466119      Int+J+Mol+Sci 2020 ; 21 (10): ä
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  • Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis #MMPMID32466119
  • Canadas O; Olmeda B; Alonso A; Perez-Gil J
  • Int J Mol Sci 2020[May]; 21 (10): ä PMID32466119show ga
  • Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air-liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid-protein and protein-protein interactions contribute to the proper maintenance of an operative respiratory surface.
  • |*Homeostasis[MESH]
  • |Alveolar Epithelial Cells/*metabolism/microbiology/physiology[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Lipid Metabolism[MESH]


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