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10.1111/dom.14097

http://scihub22266oqcxt.onion/10.1111/dom.14097
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suck abstract from ncbi


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pmid32463179      Diabetes+Obes+Metab 2020 ; 22 (10): 1946-1950
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  • Exposure to dipeptidyl-peptidase-4 inhibitors and COVID-19 among people with type 2 diabetes: A case-control study #MMPMID32463179
  • Fadini GP; Morieri ML; Longato E; Bonora BM; Pinelli S; Selmin E; Voltan G; Falaguasta D; Tresso S; Costantini G; Sparacino G; Di Camillo B; Tramontan L; Cattelan AM; Vianello A; Fioretto P; Vettor R; Avogaro A
  • Diabetes Obes Metab 2020[Oct]; 22 (10): 1946-1950 PMID32463179show ga
  • Because other coronaviruses enter the cells by binding to dipeptidyl-peptidase-4 (DPP-4), it has been speculated that DPP-4 inhibitors (DPP-4is) may exert an activity against severe acute respiratory syndrome coronavirus 2. In the absence of clinical trial results, we analysed epidemiological data to support or discard such a hypothesis. We retrieved information on exposure to DPP-4is among patients with type 2 diabetes (T2D) hospitalized for COVID-19 at an outbreak hospital in Italy. As a reference, we retrieved information on exposure to DPP-4is among matched patients with T2D in the same region. Of 403 hospitalized COVID-19 patients, 85 had T2D. The rate of exposure to DPP-4is was similar between T2D patients with COVID-19 (10.6%) and 14 857 matched patients in the region (8.8%), or 793 matched patients in the local outpatient clinic (15.4%), 8284 matched patients hospitalized for other reasons (8.5%), and when comparing 71 patients hospitalized for COVID-19 pneumonia (11.3%) with 351 matched patients with pneumonia of another aetiology (10.3%). T2D patients with COVID-19 who were on DPP-4is had a similar disease outcome as those who were not. In summary, we found no evidence that DPP-4is might affect hospitalization for COVID-19.
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*complications/diagnosis/*epidemiology[MESH]
  • |Case-Control Studies[MESH]
  • |Diabetes Mellitus, Type 2/complications/diagnosis/*drug therapy/*epidemiology[MESH]
  • |Dipeptidyl-Peptidase IV Inhibitors/*therapeutic use[MESH]
  • |Disease Outbreaks[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]


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