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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Med+Virol 2020 ; 92 (10): 2209-2215 Nephropedia Template TP
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Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam #MMPMID32462705
Phan LT; Nguyen TV; Huynh LKT; Dao MH; Vo TAN; Vu NHP; Pham HTT; Nguyen HT; Nguyen TT; Le HQ; Nguyen TV; Nguyen QH; Huynh TP; Nguyen SN; Nguyen AH; Nguyen NT; Nguyen TNT; Nguyen LT; Luong QC; Cao TM; Pham QD
J Med Virol 2020[Oct]; 92 (10): 2209-2215 PMID32462705show ga
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.