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10.1038/s41366-020-0598-3 http://scihub22266oqcxt.onion/10.1038/s41366-020-0598-3 32461554!7253147!32461554     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32461554&cmd=llinks): Failed to open stream: HTTP request failed! 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Colchicine s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial |pdf=|usr=}}{{32461554}} gab.com Text Colchicine s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial JO: Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=32461554 #FOAvip OBJECTIVE: Recent clinical trials have demonstrated that colchicine may have metabolic and cardiovascular and benefits in at-risk patients; however, the mechanisms through which colchicine may improve outcomes are still unclear. We sought to examine colchicine's effects on circulating inflammatory and metabolic molecules in adults with obesity and metabolic syndrome (MetS). METHODS: Blood samples were collected pre- and post-intervention during a double-blind randomized controlled trial in which 40 adults with obesity and MetS were randomized to colchicine 0.6 mg or placebo twice-daily for 3 months. Serum samples were analyzed for 1305 circulating factors using the SomaScan Platform. The Benjamini-Hochberg procedure was used to adjust the false discovery rate (FDR) for multiple testing. RESULTS: At baseline, age (48.0 +/- 13.8 vs. 44.7 +/- 10.3 years) and BMI (39.8 +/- 6.4 vs. 41.8 +/- 8.2 kg/m(2)) were not different between groups. After controlling for the FDR, 34 molecules were significantly changed by colchicine. Colchicine decreased concentrations of multiple inflammatory molecules, including C-reactive protein, interleukin 6, and resistin, in addition to vascular-related proteins (e.g., oxidized low-density lipoprotein receptor, phosphodiesterase 5A). Conversely, relative to placebo, colchicine significantly increased concentrations of eight molecules including secreted factors associated with metabolism and anti-thrombosis. CONCLUSIONS: In adults with obesity, colchicine significantly affected concentrations of proteins involved in the innate immune system, endothelial function and atherosclerosis, uncovering new mechanisms behind its cardiometabolic effects. Further research is warranted to investigate whether colchicine's IL-6 suppressive effects may be beneficial in COVID-19. Twit Text FOAVip Colchicine s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial ????Int J Obes (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=32461554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32461554 #FOAvip English Wikipedia <ref>{{Cite pmid|32461554}}</ref> Colchicine s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial #MMPMID32461554 Demidowich AP; Levine JA; Apps R; Cheung FK; Chen J; Fantoni G; Patel TP; Yanovski JA Int J Obes (Lond) 2020[Aug]; 44 (8): 1793-1799 PMID32461554show ga OBJECTIVE: Recent clinical trials have demonstrated that colchicine may have metabolic and cardiovascular and benefits in at-risk patients; however, the mechanisms through which colchicine may improve outcomes are still unclear. We sought to examine colchicine's effects on circulating inflammatory and metabolic molecules in adults with obesity and metabolic syndrome (MetS). METHODS: Blood samples were collected pre- and post-intervention during a double-blind randomized controlled trial in which 40 adults with obesity and MetS were randomized to colchicine 0.6 mg or placebo twice-daily for 3 months. Serum samples were analyzed for 1305 circulating factors using the SomaScan Platform. The Benjamini-Hochberg procedure was used to adjust the false discovery rate (FDR) for multiple testing. RESULTS: At baseline, age (48.0 +/- 13.8 vs. 44.7 +/- 10.3 years) and BMI (39.8 +/- 6.4 vs. 41.8 +/- 8.2 kg/m(2)) were not different between groups. After controlling for the FDR, 34 molecules were significantly changed by colchicine. Colchicine decreased concentrations of multiple inflammatory molecules, including C-reactive protein, interleukin 6, and resistin, in addition to vascular-related proteins (e.g., oxidized low-density lipoprotein receptor, phosphodiesterase 5A). Conversely, relative to placebo, colchicine significantly increased concentrations of eight molecules including secreted factors associated with metabolism and anti-thrombosis. CONCLUSIONS: In adults with obesity, colchicine significantly affected concentrations of proteins involved in the innate immune system, endothelial function and atherosclerosis, uncovering new mechanisms behind its cardiometabolic effects. Further research is warranted to investigate whether colchicine's IL-6 suppressive effects may be beneficial in COVID-19. |Adult[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |Betacoronavirus/drug effects[MESH] |C-Reactive Protein[MESH] |COVID-19[MESH] |Colchicine/pharmacology/*therapeutic use[MESH] |Coronavirus Infections/drug therapy/*immunology[MESH] |Double-Blind Method[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6[MESH] |Male[MESH] |Metabolic Syndrome/*complications/drug therapy/*immunology[MESH] |Middle Aged[MESH] |Obesity/complications/drug therapy/*immunology[MESH] |Pandemics[MESH] |Pilot Projects[MESH] |Pneumonia, Viral/drug therapy/*immunology[MESH] |SARS-CoV-2[MESH] |Treatment Outcome[MESH]Colchicine s effects on metabolic and inflammatory molecules in adults(epmc).pdf DeepDyve Pubget Overpricing