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10.1186/s13287-020-01725-4

http://scihub22266oqcxt.onion/10.1186/s13287-020-01725-4
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suck abstract from ncbi


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pmid32460839      Stem+Cell+Res+Ther 2020 ; 11 (1): 207
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  • Intravenous infusion of human umbilical cord Wharton s jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia #MMPMID32460839
  • Zhang Y; Ding J; Ren S; Wang W; Yang Y; Li S; Meng M; Wu T; Liu D; Tian S; Tian H; Chen S; Zhou C
  • Stem Cell Res Ther 2020[May]; 11 (1): 207 PMID32460839show ga
  • The novel coronavirus disease 2019 (COVID-19) has grown to be a global public health emergency since patients were first detected in Wuhan, China. Thus far, no specific drugs or vaccines are available to cure the patients with COVID-19 infection. The immune system and inflammation are proposed to play a central role in COVID-19 pathogenesis. Mesenchymal stem cells (MSCs) have been shown to possess a comprehensive powerful immunomodulatory function. Intravenous infusion of MSCs has shown promising results in COVID-19 treatment. Here, we report a case of a severe COVID-19 patient treated with human umbilical cord Wharton's jelly-derived MSCs (hWJCs) from a healthy donor in Liaocheng People's Hospital, China, from February 24, 2020. The pulmonary function and symptoms of the patient with COVID-19 pneumonia was significantly improved in 2 days after hWJC transplantation, and recovered and discharged in 7 days after treatment. After treatment, the percentage and counts of lymphocyte subsets (CD3(+), CD4(+), and CD8(+) T cell) were increased, and the level of IL-6, TNF-alpha, and C-reactive protein is significantly decreased after hWJC treatment. Thus, the intravenous transplantation of hWJCs was safe and effective for the treatment of patients with COVID-19 pneumonia, especially for the patients in a critically severe condition. This report highlights the potential of hWJC infusions as an effective treatment for COVID-19 pneumonia.
  • |Betacoronavirus/genetics/*pathogenicity[MESH]
  • |C-Reactive Protein/immunology/metabolism[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/diagnosis/drug therapy/immunology/*therapy[MESH]
  • |Humans[MESH]
  • |Immunomodulation[MESH]
  • |Infusions, Intravenous[MESH]
  • |Interleukin-6/blood/immunology[MESH]
  • |Lymphocyte Subsets/immunology/virology[MESH]
  • |Male[MESH]
  • |Mesenchymal Stem Cell Transplantation/*methods[MESH]
  • |Mesenchymal Stem Cells/*cytology/immunology[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/immunology/*therapy[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]
  • |Tumor Necrosis Factor-alpha/blood/immunology[MESH]
  • |Umbilical Cord/cytology/immunology[MESH]


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