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10.1111/tri.13662

http://scihub22266oqcxt.onion/10.1111/tri.13662
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suck abstract from ncbi


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pmid32460390      Transpl+Int 2020 ; 33 (9): 1099-1105
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  • COVID-19 in solid organ transplant recipients: a single-center experience #MMPMID32460390
  • Hoek RAS; Manintveld OC; Betjes MGH; Hellemons ME; Seghers L; Van Kampen JAA; Caliskan K; van de Wetering J; van den Hoogen M; Metselaar HJ; Hesselink DA
  • Transpl Int 2020[Sep]; 33 (9): 1099-1105 PMID32460390show ga
  • Solid organ transplant (SOT) recipients may be at risk for severe COVID-19. Data on the clinical course of COVID-19 in immunosuppressed patients are limited, and the effective treatment strategy for these patients is unknown. We describe our institutional experience with COVID-19 in SOT. Demographic, clinical, and treatment data were extracted from the electronic patient files. A total of 23 SOT transplant recipients suffering from COVID-19 were identified (n = 3 heart; n = 15 kidney; n = 1 kidney-after-heart; n = 3 lung, and n = 1 liver transplant recipient). The presenting symptoms were similar to nonimmunocompromised patients. Eighty-three percent (19/23) of the patients required hospitalization, but only two of these were transferred to the intensive care unit. Five patients died from COVID-19; all had high Clinical Frailty Scores. In four of these patients, mechanical ventilation was deemed futile. In 57% of patients, the immunosuppressive therapy was not changed and only three patients were treated with chloroquine. Most patients recovered without experimental antiviral therapy. Modification of the immunosuppressive regimen alone could be a therapeutic option for SOT recipients suffering from moderate to severe COVID-19. Pre-existent frailty is associated with death from COVID-19.
  • |*Transplant Recipients[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*epidemiology/immunology/therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunosuppression Therapy/*adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Netherlands/epidemiology[MESH]
  • |Organ Transplantation/*adverse effects[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]
  • |Treatment Outcome[MESH]


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