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10.1152/ajpendo.00198.2020 http://scihub22266oqcxt.onion/10.1152/ajpendo.00198.2020 32459524!7322508!32459524     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Endocrinol+Metab 2020 ; 319 (1): E105-E109 Nephropedia Template TP {{tp|p=32459524|t=2020. Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes |pdf=|usr=}}{{32459524}} gab.com Text Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=32459524 #FOAvip Recent reports have shown a strong association between obesity and the severity of COVID-19 infection, even in the absence of other comorbidities. After infecting the host cells, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause a hyperinflammatory reaction through the excessive release of cytokines, a condition known as "cytokine storm," while inducing lymphopenia and a disrupted immune response. Obesity is associated with chronic low-grade inflammation and immune dysregulation, but the exact mechanisms through which it exacerbates COVID-19 infection are not fully clarified. The production of increased amounts of cytokines such as TNFalpha, IL-1, IL-6, and monocyte chemoattractant protein (MCP-1) lead to oxidative stress and defective function of innate and adaptive immunity, whereas the activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome seems to play a crucial role in the pathogenesis of the infection. Endothelial dysfunction and arterial stiffness could favor the recently discovered infection of the endothelium by SARS-CoV-2, whereas alterations in cardiac structure and function and the prothrombotic microenvironment in obesity could provide a link for the increased cardiovascular events in these patients. The successful use of anti-inflammatory agents such as IL-1 and IL-6 blockers in similar hyperinflammatory settings, like that of rheumatoid arthritis, has triggered the discussion of whether such agents could be administrated in selected patients with COVID-19 disease. Twit Text FOAVip Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=32459524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32459524 #FOAvip English Wikipedia <ref>{{Cite pmid|32459524}}</ref> Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes #MMPMID32459524 Korakas E; Ikonomidis I; Kousathana F; Balampanis K; Kountouri A; Raptis A; Palaiodimou L; Kokkinos A; Lambadiari V Am J Physiol Endocrinol Metab 2020[Jul]; 319 (1): E105-E109 PMID32459524show ga Recent reports have shown a strong association between obesity and the severity of COVID-19 infection, even in the absence of other comorbidities. After infecting the host cells, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause a hyperinflammatory reaction through the excessive release of cytokines, a condition known as "cytokine storm," while inducing lymphopenia and a disrupted immune response. Obesity is associated with chronic low-grade inflammation and immune dysregulation, but the exact mechanisms through which it exacerbates COVID-19 infection are not fully clarified. The production of increased amounts of cytokines such as TNFalpha, IL-1, IL-6, and monocyte chemoattractant protein (MCP-1) lead to oxidative stress and defective function of innate and adaptive immunity, whereas the activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome seems to play a crucial role in the pathogenesis of the infection. Endothelial dysfunction and arterial stiffness could favor the recently discovered infection of the endothelium by SARS-CoV-2, whereas alterations in cardiac structure and function and the prothrombotic microenvironment in obesity could provide a link for the increased cardiovascular events in these patients. The successful use of anti-inflammatory agents such as IL-1 and IL-6 blockers in similar hyperinflammatory settings, like that of rheumatoid arthritis, has triggered the discussion of whether such agents could be administrated in selected patients with COVID-19 disease. |Adaptive Immunity[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/metabolism/*physiopathology[MESH] |Cytokine Release Syndrome/virology[MESH] |Endothelium/physiopathology[MESH] |Heart/physiopathology/virology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/immunology[MESH] |Obesity/*virology[MESH] |Oxidative Stress[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/metabolism/*physiopathology[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Thrombosis/physiopathology[MESH]Obesity and COVID-19: immune and metabolic derangement as a possible l(epmc).pdf DeepDyve Pubget Overpricing