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10.2144/btn-2020-0038 http://scihub22266oqcxt.onion/10.2144/btn-2020-0038 32459144!7273901!32459144     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biotechniques 2020 ; 69 (2): 108-112 Nephropedia Template TP {{tp|p=32459144|t=2020. Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking |pdf=|usr=}}{{32459144}} gab.com Text Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking JO: Biotechniques http://www.kidney.de/pget.php?&tw=1&pmid=32459144 #FOAvip The outbreak of viral pneumonia caused by the novel coronavirus SARS-CoV-2 that began in December 2019 caused high mortality. It has been suggested that the main protease (Mpro) of SARS-CoV-2 may be an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. Remdesivir, ritonavir and chloroquine have all been reported to play a role in suppressing SARS-CoV-2. Here, we applied a molecular docking method to study the binding stability of these drugs with SARS-CoV-2 Mpro. It appeared that the ligand-protein binding stability of the alliin and SARS-CoV-2 Mpro complex was better than others. The results suggested that alliin may serve as a good candidate as an inhibitor of SARS-CoV-2 Mpro. Therefore, the present research may provide some meaningful guidance for the prevention and treatment of SARS-CoV-2. Twit Text FOAVip Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking ????Biotechniques http://www.kidney.de/pget.php?&tw=1&pmid=32459144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32459144 #FOAvip English Wikipedia <ref>{{Cite pmid|32459144}}</ref> Discovery of alliin as a putative inhibitor of the main protease of SARS-CoV-2 by molecular docking #MMPMID32459144 Cheng B; Li T Biotechniques 2020[Aug]; 69 (2): 108-112 PMID32459144show ga The outbreak of viral pneumonia caused by the novel coronavirus SARS-CoV-2 that began in December 2019 caused high mortality. It has been suggested that the main protease (Mpro) of SARS-CoV-2 may be an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. Remdesivir, ritonavir and chloroquine have all been reported to play a role in suppressing SARS-CoV-2. Here, we applied a molecular docking method to study the binding stability of these drugs with SARS-CoV-2 Mpro. It appeared that the ligand-protein binding stability of the alliin and SARS-CoV-2 Mpro complex was better than others. The results suggested that alliin may serve as a good candidate as an inhibitor of SARS-CoV-2 Mpro. Therefore, the present research may provide some meaningful guidance for the prevention and treatment of SARS-CoV-2. |Adenosine Monophosphate/analogs & derivatives/pharmacology[MESH] |Alanine/analogs & derivatives/pharmacology[MESH] |Antimalarials/pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/enzymology[MESH] |Chloroquine/pharmacology[MESH] |Coronavirus 3C Proteases[MESH] |Cysteine Endopeptidases[MESH] |Cysteine/*analogs & derivatives/pharmacology[MESH] |Molecular Docking Simulation[MESH] |Ritonavir/pharmacology[MESH] |SARS-CoV-2[MESH]Discovery of alliin as a putative inhibitor of the main protease of SA(epmc).pdf DeepDyve Pubget Overpricing