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  • A role for retinoids in the treatment of COVID-19? #MMPMID32459003
  • Trasino SE
  • Clin Exp Pharmacol Physiol 2020[Oct]; 47 (10): 1765-1767 PMID32459003show ga
  • The 2020 global outbreak of the novel coronavirus (SARS-CoV-2 or COVID-19) is a serious threat to international health, and thus, there is an urgent need for discovery of novel therapies or use of repurposed drugs that can make a significant impact on slowing the spread of the virus. Type 1 interferons (IFN-I) are a family cytokines of the early innate immune response to viruses that are being tested against SARS-CoV-2. However, coronaviruses similar to SARS-CoV-2 can suppress host IFN-I antiviral responses. Retinoids are a family molecules related to vitamin A that possess robust immune-modulating properties, including the ability to increase and potentiate the actions of IFN-I. Therefore, adjuvants such as retinoids, capable of increasing IFN-I-mediated antiviral responses, should be tested in combinations of IFN-I and antiviral drugs in pre-clinical studies of SARS-CoV-2.
  • |*Betacoronavirus/drug effects[MESH]
  • |Antiviral Agents/pharmacology/*therapeutic use[MESH]
  • |Clinical Trials as Topic/methods[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/pharmacology/therapeutic use[MESH]
  • |Interferon Type I/pharmacology/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy[MESH]
  • |Retinoids/pharmacology/*therapeutic use[MESH]
  • |Treatment Outcome[MESH]

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  • suck abstract from ncbi

    1765 10.47 2020