Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.23812/20-221-L-49 http://scihub22266oqcxt.onion/10.23812/20-221-L-49 32456409!ä!32456409 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Regul+Homeost+Agents 2020 ; 34 (3): 1125-1129 Nephropedia Template TP {{tp|p=32456409|t=2020. A theory on SARS-COV-2 susceptibility: reduced TLR7-activity as a mechanistic link between men, obese and elderly |pdf=|usr=}}{{32456409}} gab.com Text A theory on SARS-COV-2 susceptibility: reduced TLR7-activity as a mechanistic link between men, obese and elderly JO: J Biol Regul Homeost Agents http://www.kidney.de/pget.php?&tw=1&pmid=32456409 #FOAvip I hypothesize that chronic stimulation of tlr7 by intrinsic substrates in old and obese people leads to a desensitization of tlr7-signalling such that upon viral infection the immune response in those patients will be delayed, allowing the virus to more easily establish itself in these at-risk patient groups. Upon severe viral infection, resensitization of tlr7-signalling occurs so as to better fight the viral infection. This, however, leads to a situation where old and obese patients develop an overwhelming tlr7-response due to the presence of not only the viral RNA, but also the intrinsic tlr7 substrates. Thus, old and obese patients with serious COVID-19 develop a state that is similar to SLE-patients and consequently should be treated in a similar manner. The theory predicts that drugs and treatment regimens that help to control SLE-flares might also help in late-stage COVID-19 patients. Twit Text FOAVip A theory on SARS-COV-2 susceptibility: reduced TLR7-activity as a mechanistic link between men, obese and elderly ????J Biol Regul Homeost Agents http://www.kidney.de/pget.php?&tw=1&pmid=32456409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32456409 #FOAvip English Wikipedia <ref>{{Cite pmid|32456409}}</ref> A theory on SARS-COV-2 susceptibility: reduced TLR7-activity as a mechanistic link between men, obese and elderly #MMPMID32456409 Englmeier L J Biol Regul Homeost Agents 2020[May]; 34 (3): 1125-1129 PMID32456409show ga I hypothesize that chronic stimulation of tlr7 by intrinsic substrates in old and obese people leads to a desensitization of tlr7-signalling such that upon viral infection the immune response in those patients will be delayed, allowing the virus to more easily establish itself in these at-risk patient groups. Upon severe viral infection, resensitization of tlr7-signalling occurs so as to better fight the viral infection. This, however, leads to a situation where old and obese patients develop an overwhelming tlr7-response due to the presence of not only the viral RNA, but also the intrinsic tlr7 substrates. Thus, old and obese patients with serious COVID-19 develop a state that is similar to SLE-patients and consequently should be treated in a similar manner. The theory predicts that drugs and treatment regimens that help to control SLE-flares might also help in late-stage COVID-19 patients. |*COVID-19[MESH] |*Disease Susceptibility[MESH] |*Toll-Like Receptor 7/genetics[MESH] |Aged[MESH] |Humans[MESH] |Male[MESH]A theory on SARS-COV-2 susceptibility: reduced TLR7-activity as a mech(epmc).pdf DeepDyve Pubget Overpricing