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10.3390/v12050576 http://scihub22266oqcxt.onion/10.3390/v12050576 32456286!7290745!32456286     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (5): ä Nephropedia Template TP {{tp|p=32456286|t=2020. Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection |pdf=|usr=}}{{32456286}} gab.com Text Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32456286 #FOAvip Feline infectious peritonitis (FIP) is a viral disease with a high morbidity and mortality by the FIP virus (FIPV, virulent feline coronavirus). Several antiviral drugs for FIP have been identified, but many of these are expensive and not available in veterinary medicine. Hydroxychloroquine (HCQ) is a drug approved by several countries to treat malaria and immune-mediated diseases in humans, and its antiviral effects on other viral infections (e.g., SARS-CoV-2, dengue virus) have been confirmed. We investigated whether HCQ in association with interferon-omega (IFN-omega) is effective for FIPV in vitro. A total of 100 muM of HCQ significantly inhibited the replication of types I and II FIPV. Interestingly, the combination of 100 muM of HCQ and 10(4) U/mL of recombinant feline IFN-omega (rfIFN-omega, veterinary registered drug) increased its antiviral activity against type I FIPV infection. Our study suggested that HCQ and rfIFN-omega are applicable for treatment of FIP. Further clinical studies are needed to verify the combination of HCQ and rIFN-omega will be effective and safe treatment for cats with FIP. Twit Text FOAVip Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32456286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32456286 #FOAvip English Wikipedia <ref>{{Cite pmid|32456286}}</ref> Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection #MMPMID32456286 Takano T; Satoh K; Doki T; Tanabe T; Hohdatsu T Viruses 2020[May]; 12 (5): ä PMID32456286show ga Feline infectious peritonitis (FIP) is a viral disease with a high morbidity and mortality by the FIP virus (FIPV, virulent feline coronavirus). Several antiviral drugs for FIP have been identified, but many of these are expensive and not available in veterinary medicine. Hydroxychloroquine (HCQ) is a drug approved by several countries to treat malaria and immune-mediated diseases in humans, and its antiviral effects on other viral infections (e.g., SARS-CoV-2, dengue virus) have been confirmed. We investigated whether HCQ in association with interferon-omega (IFN-omega) is effective for FIPV in vitro. A total of 100 muM of HCQ significantly inhibited the replication of types I and II FIPV. Interestingly, the combination of 100 muM of HCQ and 10(4) U/mL of recombinant feline IFN-omega (rfIFN-omega, veterinary registered drug) increased its antiviral activity against type I FIPV infection. Our study suggested that HCQ and rfIFN-omega are applicable for treatment of FIP. Further clinical studies are needed to verify the combination of HCQ and rIFN-omega will be effective and safe treatment for cats with FIP. |Analysis of Variance[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology/therapeutic use/toxicity[MESH] |Cats[MESH] |Cell Line/drug effects[MESH] |Coronavirus Infections/drug therapy/virology[MESH] |Coronavirus, Feline/*drug effects/pathogenicity[MESH] |Drug Combinations[MESH] |Feline Infectious Peritonitis/drug therapy/virology[MESH] |Fluorescent Antibody Technique/veterinary[MESH] |Hydroxychloroquine/*pharmacology/therapeutic use/toxicity[MESH] |Interferon Type I/*pharmacology/therapeutic use/toxicity[MESH]Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vi(epmc).pdf DeepDyve Pubget Overpricing