Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1038/s41586-020-2380-z

http://scihub22266oqcxt.onion/10.1038/s41586-020-2380-z
suck pdf from google scholar
32454513!ä!32454513

suck abstract from ncbi


Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid32454513      Nature 2020 ; 584 (7819): 115-119
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Human neutralizing antibodies elicited by SARS-CoV-2 infection #MMPMID32454513
  • Ju B; Zhang Q; Ge J; Wang R; Sun J; Ge X; Yu J; Shan S; Zhou B; Song S; Tang X; Yu J; Lan J; Yuan J; Wang H; Zhao J; Zhang S; Wang Y; Shi X; Liu L; Zhao J; Wang X; Zhang Z; Zhang L
  • Nature 2020[Aug]; 584 (7819): 115-119 PMID32454513show ga
  • The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that is in urgent need of intervention(1-3). The entry of SARS-CoV-2 into its target cells depends on binding between the receptor-binding domain (RBD) of the viral spike protein and its cellular receptor, angiotensin-converting enzyme 2 (ACE2)(2,4-6). Here we report the isolation and characterization of 206 RBD-specific monoclonal antibodies derived from single B cells from 8 individuals infected with SARS-CoV-2. We identified antibodies that potently neutralize SARS-CoV-2; this activity correlates with competition with ACE2 for binding to RBD. Unexpectedly, the anti-SARS-CoV-2 antibodies and the infected plasma did not cross-react with the RBDs of SARS-CoV or Middle East respiratory syndrome-related coronavirus (MERS-CoV), although there was substantial plasma cross-reactivity to their trimeric spike proteins. Analysis of the crystal structure of RBD-bound antibody revealed that steric hindrance inhibits viral engagement with ACE2, thereby blocking viral entry. These findings suggest that anti-RBD antibodies are largely viral-species-specific inhibitors. The antibodies identified here may be candidates for development of clinical interventions against SARS-CoV-2.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antibodies, Neutralizing/chemistry/*immunology[MESH]
  • |Antibodies, Viral/chemistry/*immunology[MESH]
  • |B-Lymphocytes/cytology/immunology[MESH]
  • |Betacoronavirus/chemistry/*immunology[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Clone Cells/cytology/immunology[MESH]
  • |Coronavirus Infections/*immunology/*virology[MESH]
  • |Cross Reactions[MESH]
  • |Crystallization[MESH]
  • |Crystallography, X-Ray[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Models, Molecular[MESH]
  • |Neutralization Tests[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH]
  • |Plasma/immunology[MESH]
  • |Pneumonia, Viral/*immunology/*virology[MESH]
  • |SARS-CoV-2[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box