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10.1016/j.lfs.2020.117842 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.117842 32454157!7245231!32454157     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2020 ; 255 (ä): 117842 Nephropedia Template TP {{tp|p=32454157|t=2020. Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 |pdf=|usr=}}{{32454157}} gab.com Text Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32454157 #FOAvip The outbreak of COVID-19 caused by 2019-nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca(++) caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19. Twit Text FOAVip Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32454157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32454157 #FOAvip English Wikipedia <ref>{{Cite pmid|32454157}}</ref> Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 #MMPMID32454157 Banerjee A; Czinn SJ; Reiter RJ; Blanchard TG Life Sci 2020[Aug]; 255 (ä): 117842 PMID32454157show ga The outbreak of COVID-19 caused by 2019-nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. Viral infections including SARS-CoV are associated with increased levels of reactive oxygen species, disturbances of Ca(++) caused by unfolded protein response (UPR) mediated by endoplasmic reticulum (ER) stress and is due to the exploitation of virus's own protein i.e., viroporins into the host cells. Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. Unfortunately, each drug has specific limitations. Herein, we review the viral protein involvement to activate ER stress transducers (IRE-1, PERK, ATF-6) and their downstream signals; and evaluate combination therapies for COVID-19 mediated ER stress alterations. Melatonin is an immunoregulator, anti-pyretic, antioxidant, anti-inflammatory and ER stress modulator during viral infections. It enhances protective mechanisms for respiratory tract disorders. Andrographolide, isolated from Andrographis paniculata, has versatile biological activities including immunomodulation and determining SARS-CoV-2 binding site. Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19. |Activating Transcription Factor 6/metabolism[MESH] |Antiviral Agents/pharmacology[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/*virology[MESH] |Diterpenes/*pharmacology[MESH] |Drug Synergism[MESH] |Endoplasmic Reticulum Stress/*drug effects/physiology[MESH] |Endoribonucleases/metabolism[MESH] |Humans[MESH] |Melatonin/*pharmacology[MESH] |Molecular Targeted Therapy[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/*virology[MESH] |Protein Serine-Threonine Kinases/metabolism[MESH] |SARS-CoV-2[MESH] |Unfolded Protein Response/drug effects[MESH]Crosstalk between endoplasmic reticulum stress and anti-viral activiti(epmc).pdf DeepDyve Pubget Overpricing