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10.1016/j.bbi.2020.05.059

http://scihub22266oqcxt.onion/10.1016/j.bbi.2020.05.059
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32454138!7245300!32454138
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suck abstract from ncbi


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pmid32454138      Brain+Behav+Immun 2020 ; 87 (ä): 184-187
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  • Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK #MMPMID32454138
  • Hamer M; Kivimaki M; Gale CR; Batty GD
  • Brain Behav Immun 2020[Jul]; 87 (ä): 184-187 PMID32454138show ga
  • We conducted the first large-scale general population study on lifestyle risk factors (smoking, physical inactivity, obesity, and excessive alcohol intake) for COVID-19 using prospective cohort data with national registry linkage to hospitalisation. Participants were 387,109 men and women (56.4 +/- 8.8 yr; 55.1% women) residing in England from UK Biobank study. Physical activity, smoking, and alcohol intake, were assessed by questionnaire at baseline (2006-2010). Body mass index, from measured height and weight, was used as an indicator of overall obesity. Outcome was cases of COVID-19 serious enough to warrant a hospital admission from 16-March-2020 to 26-April-2020. There were 760 COVID-19 cases. After adjustment for age, sex and mutually for each lifestyle factor, physical inactivity (Relative risk, 1.32, 95% confidence interval, 1.10, 1.58), smoking (1.42;1.12, 1.79) and obesity (2.05 ;1.68, 2.49) but not heavy alcohol consumption (1.12; 0.93, 1.35) were all related to COVID-19. We also found a dose-dependent increase in risk of COVID-19 with less favourable lifestyle scores, such that participants in the most adverse category had 4-fold higher risk (4.41; 2.52-7.71) compared to people with the most optimal lifestyle. C-reactive protein levels were associated with elevated risk of COVID-19 in a dose-dependent manner, and partly (10-16%) explained associations between adverse lifestyle and COVID-19. Based on UK risk factor prevalence estimates, unhealthy behaviours in combination accounted for up to 51% of the population attributable fraction of severe COVID-19. Our findings suggest that an unhealthy lifestyle synonymous with an elevated risk of non-communicable disease is also a risk factor for COVID-19 hospital admission, which might be partly explained by low grade inflammation. Adopting simple lifestyle changes could lower the risk of severe infection.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Alcohol Drinking/adverse effects[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |Body Mass Index[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*epidemiology[MESH]
  • |Exercise/psychology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Life Style[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Obesity/psychology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology[MESH]
  • |Prospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Smoking/epidemiology[MESH]
  • |Surveys and Questionnaires[MESH]


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