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10.1111/bjh.16885

http://scihub22266oqcxt.onion/10.1111/bjh.16885
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32453877!7283673!32453877
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  • Delayed-phase thrombocytopenia in patients with coronavirus disease 2019 (COVID-19) #MMPMID32453877
  • Chen W; Li Z; Yang B; Wang P; Zhou Q; Zhang Z; Zhu J; Chen X; Yang P; Zhou H
  • Br J Haematol 2020[Jul]; 190 (2): 179-184 PMID32453877show ga
  • Coronavirus disease 2019 (COVID-19) can affect the haematopoietic system. Thrombocytopenia at admission was prevalent, while late-phase or delayed-phase thrombocytopenia (occurred 14 days after symptom onset) is rare. This retrospective, single-centre study screened 450 COVID-19 patients and enrolled 271 patients at the Union Hospital, Wuhan, China, from January 25 to March 9, 2020. COVID-19-associated delayed-phase thrombocytopenia occurred in 11.8% of enrolling patients. The delayed-phase thrombocytopenia in COVID-19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed-phase thrombocytopenia is significantly associated with increased length of hospital stay and higher mortality rate. Delayed-phase nadir platelet counts demonstrated a significantly negative correlation with B cell percentages. We also provided and described bone marrow aspiration pathology of three patients with delayed-phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that immune-mediated platelet destruction might account for the delayed-phase thrombocytopenia in a group of patients. In addition, clinicians need to pay attention to the delayed-phase thrombocytopenia especially at 3-4 weeks after symptom onset.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |Bone Marrow/pathology[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Platelet Count[MESH]
  • |Pneumonia, Viral/*complications[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Thrombocytopenia/*diagnosis/*virology[MESH]


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  • suck abstract from ncbi

    179 2.190 2020