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10.1016/j.virol.2020.04.009 http://scihub22266oqcxt.onion/10.1016/j.virol.2020.04.009 32452420!7194111!32452420     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2020 ; 546 (ä): 88-97 Nephropedia Template TP {{tp|p=32452420|t=2020. Antiviral activity of lycorine against Zika virus in vivo and in vitro |pdf=|usr=}}{{32452420}} gab.com Text Antiviral activity of lycorine against Zika virus in vivo and in vitro JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=32452420 #FOAvip The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas worldwide. Despite these burdens, antiviral therapies do not exist, and inhibitors of ZIKV are therefore urgently needed. To elucidate the anti-ZIKV effect of lycorine, we used reverse transcription-quantitative real-time PCR (qRT-PCR), immunofluorescence, (Western)(western) blot, and plaque forming assay to analyse viral RNA (vRNA), viral protein, progeny virus counts, and validated inhibitors in vitro using a variety of cell lines. Additionally, we found that lycorine acts post-infection according to time-of-addition assay, and inhibits RdRp activity. Lycorine protected AG6 mice against ZIKV-induced lethality by decreasing the viral load in the blood. Due to its potency and ability to target ZIKV infection in vivo and in vitro, lycorine might offer promising therapeutic possibilities for combatting ZIKV infections in the future. Twit Text FOAVip Antiviral activity of lycorine against Zika virus in vivo and in vitro ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=32452420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32452420 #FOAvip English Wikipedia <ref>{{Cite pmid|32452420}}</ref> Antiviral activity of lycorine against Zika virus in vivo and in vitro #MMPMID32452420 Chen H; Lao Z; Xu J; Li Z; Long H; Li D; Lin L; Liu X; Yu L; Liu W; Li G; Wu J Virology 2020[Jul]; 546 (ä): 88-97 PMID32452420show ga The emergence and re-emergence of Zika virus (ZIKV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas worldwide. Despite these burdens, antiviral therapies do not exist, and inhibitors of ZIKV are therefore urgently needed. To elucidate the anti-ZIKV effect of lycorine, we used reverse transcription-quantitative real-time PCR (qRT-PCR), immunofluorescence, (Western)(western) blot, and plaque forming assay to analyse viral RNA (vRNA), viral protein, progeny virus counts, and validated inhibitors in vitro using a variety of cell lines. Additionally, we found that lycorine acts post-infection according to time-of-addition assay, and inhibits RdRp activity. Lycorine protected AG6 mice against ZIKV-induced lethality by decreasing the viral load in the blood. Due to its potency and ability to target ZIKV infection in vivo and in vitro, lycorine might offer promising therapeutic possibilities for combatting ZIKV infections in the future. |Amaryllidaceae Alkaloids/*administration & dosage/chemistry[MESH] |Animals[MESH] |Antiviral Agents/*administration & dosage/chemistry[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Molecular Docking Simulation[MESH] |Phenanthridines/*administration & dosage/chemistry[MESH] |Virus Replication/drug effects[MESH] |Zika Virus Infection/*drug therapy/mortality/virology[MESH]Antiviral activity of lycorine against Zika virus in vivo and in vitro(epmc).pdf DeepDyve Pubget Overpricing